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Literature DB >> 13972632

Studies on immunity in anthrax. X. Gel-adsorbed protective antigen for immunization of man.

Abstract

Puziss, Milton (Fort Detrick, Frederick, Md.) and George G. Wright. Studies on immunity in anthrax. X. Gel-adsorbed protective antigen for immunization of man. J. Bacteriol. 85:230-236. 1963.-Protective antigen in filtrates of anaerobic cultures of Bacillus anthracis was not readily precipitable by alum or other aluminum salts, but was adsorbed onto a preformed aluminum hydroxide gel under specific conditions. The adsorbed product was highly effective in immunizing rabbits, guinea pigs, and mice against challenge with virulent B. anthracis spores. Gel-adsorbed anaerobic antigens preserved with 1:10,000 thimerosal were unstable on storage at 4 C; replacement of this preservative with 1:40,000 benzethonium chloride produced a more stable product. Addition of 0.0009% formalin further increased the stability during accelerated aging at 37 C. The final product had high protective activity in animals and was well tolerated in man.

Entities: Chemical Species

Keywords: ANTIGENS; BACILLUS ANTHRACIS

Mesh：

Substances：

Year: 1963 PMID： 13972632 PMCID： PMC278112 DOI： 10.1128/jb.85.1.230-236.1963

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

12 in total

1. Purification of factor I and recognition of a third factor of the anthrax toxin.

Authors: J L STANLEY; H SMITH
Journal: J Gen Microbiol Date: 1961-09

2. Production of toxin in vitro by Bacillus anthracis and its spearation into two components.

Authors: C B THORNE; D M MOLNAR; R E STRANGE
Journal: J Bacteriol Date: 1960-03 Impact factor: 3.490

3. Studies on immunity to toxins of Clostridium botulinum. V. Detoxification of purified type A and type B toxins, and the antigenicity of univalent and bivalent aluminium phosphate adsorbed toxoids.

Authors: G G WRIGHT; J T DUFF; M A FIOCK; H B DEVLIN; R L SODERSTROM
Journal: J Immunol Date: 1960-04 Impact factor: 5.422

4. The serological relationship between purified preparations of factors I and II of the anthrax toxin produced in vivo and in vitro.

Authors: K SARGEANT; J L STANLEY; H SMITH
Journal: J Gen Microbiol Date: 1960-02

5. An agar-diffusion method for titrating Bacillus anthracis immunizing antigen and its application to a study of antigen production.

Authors: C B THORNE; F C BELTON
Journal: J Gen Microbiol Date: 1957-10

6. Studies on immunity in anthrax. V. Immunizing activity of alum-precipitated protective antigen.

Authors: G G WRIGHT; T W GREEN; R G KANODE
Journal: J Immunol Date: 1954-12 Impact factor: 5.422

7. The preservation of poliomyelitis vaccine with stabilized merthiolate.

Authors: E O DAVISSON; H M POWELL; J O MACFARLANE; R HODGSON; R L STONE; C G CULBERTSON
Journal: J Lab Clin Med Date: 1956-01

8. Field Evaluation of a Human Anthrax Vaccine.

Authors: P S Brachman; H Gold; S A Plotkin; F R Fekety; M Werrin; N R Ingraham
Journal: Am J Public Health Nations Health Date: 1962-04

9. Studies on immunity in anthrax. IX. Effect of variations in cultural conditions on elaboration of protective antigen by strains of Bacillus anthracis.

Authors: G G WRIGHT; M PUZISS; W B NEELY
Journal: J Bacteriol Date: 1962-03 Impact factor: 3.490

10. Studies on immunity in anthrax. VII. Carbohydrate metabolism of Bacillus anthracis in relation to elaboration of protective antigen.

Authors: M PUZISS; G G WRIGHT
Journal: J Bacteriol Date: 1959-07 Impact factor: 3.490

21 in total

Review 1. Development of an improved vaccine for anthrax.

Authors: Stephen H Leppla; John B Robbins; Rachel Schneerson; Joseph Shiloach
Journal: J Clin Invest Date: 2002-07 Impact factor: 14.808

2. Large-scale production of protective antigen of Bacillus anthracis in anaerobic cultures.

Authors: M PUZISS; L C MANNING; J W LYNCH; I ABELOW; G G WRIGHT
Journal: Appl Microbiol Date: 1963-07

3. Immunogenicity of recombinant protective antigen and efficacy against aerosol challenge with anthrax.

Authors: E D Williamson; I Hodgson; N J Walker; A W Topping; M G Duchars; J M Mott; J Estep; C Lebutt; H C Flick-Smith; H E Jones; H Li; C P Quinn
Journal: Infect Immun Date: 2005-09 Impact factor: 3.441

Review 4. Genetic medicine strategies to protect against bioterrorism.

Authors: Julie L Boyer; Ronald G Crystal
Journal: Trans Am Clin Climatol Assoc Date: 2006

5. A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins.

Authors: Andrei P Pomerantsev; Olga M Pomerantseva; Mahtab Moayeri; Rasem Fattah; Cynthia Tallant; Stephen H Leppla
Journal: Protein Expr Purif Date: 2011-08-07 Impact factor: 1.650

6. Comparative efficacy of Bacillus anthracis live spore vaccine and protective antigen vaccine against anthrax in the guinea pig.

Authors: S F Little; G B Knudson
Journal: Infect Immun Date: 1986-05 Impact factor: 3.441

7. Development of antibodies to protective antigen and lethal factor components of anthrax toxin in humans and guinea pigs and their relevance to protective immunity.

Authors: P C Turnbull; M G Broster; J A Carman; R J Manchee; J Melling
Journal: Infect Immun Date: 1986-05 Impact factor: 3.441

8. Induction of protective immunity to anthrax lethal toxin with a nonhuman primate adenovirus-based vaccine in the presence of preexisting anti-human adenovirus immunity.

Authors: Masahiko Hashimoto; Julie L Boyer; Neil R Hackett; James M Wilson; Ronald G Crystal
Journal: Infect Immun Date: 2005-10 Impact factor: 3.441

9. Comparison of enzyme-linked immunosorbent and indirect hemagglutination assays for determining anthrax antibodies.

Authors: A Johnson-Winegar
Journal: J Clin Microbiol Date: 1984-09 Impact factor: 5.948

10. Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.

Authors: Rachel Schneerson; Joanna Kubler-Kielb; Teh-Yung Liu; Zhong-Dong Dai; Stephen H Leppla; Alfred Yergey; Peter Backlund; Joseph Shiloach; Fathy Majadly; John B Robbins
Journal: Proc Natl Acad Sci U S A Date: 2003-07-11 Impact factor: 11.205