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Literature DB >> 13971349

Facilitation of neuromuscular transmission by anticholinesterase drugs.

Abstract

A close correlation has been shown to exist between the in vitro anticholinesterase potencies of ambenonium, neostigmine, methoxyambenonium and edrophonium chloride and their abilities to increase muscle contractions produced by close-arterial injections of acetylcholine. No correlation was found between the anticholinesterase potencies of the drugs and their potentiations of the maximal twitch in response to electrical stimulation, or their antagonisms of tubocurarine. It is concluded that some action, in addition to inhibition of cholinesterase, contributed to their facilitation at the neuromuscular junction, and it is suggested that this action may be at the prejunctional site.

Entities: Chemical Gene

Keywords: ACETYLCHOLINE; CURARIFORM ANTAGONISTS; MYONEURAL JUNCTION; NEOSTIGMINE; PARASYMPATHOMIMETICS; TUBOCURARINE

Mesh：

Substances：

Year: 1963 PMID： 13971349 PMCID： PMC1703737 DOI： 10.1111/j.1476-5381.1963.tb01297.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

22 in total

1. Removal of acetylcholine from a limited volume by diffusion.

Authors: A G OGSTON
Journal: J Physiol Date: 1955-04-28 Impact factor: 5.182

2. The interaction between benzoquinonium and anticholinesterases in skeletal muscle.

Authors: L C BLABER; W C BOWMAN
Journal: Arch Int Pharmacodyn Ther Date: 1962-07-01

3. A comparison between the responses of avian and mammalian muscles to substances with facilitate neuromuscular transmission.

Authors: L C BLABER; W C BOWMAN
Journal: Arch Int Pharmacodyn Ther Date: 1962-07-01

4. Neuromuscular facilitation and antidromic discharges in motor nerves: their relation to activity in motor nerve terminals.

Authors: G WERNER
Journal: J Neurophysiol Date: 1960-03 Impact factor: 2.714

10. Studies on the interrelationship of certain cholinergic compounds; the pharmacology of 3-acetoxy phenyltrimethylammonium methylsulfate.

Authors: W C WESCOE; W F RIKER; M J BROTHERS
Journal: J Pharmacol Exp Ther Date: 1949-10 Impact factor: 4.030

1 in total

1. THE EFFECTS OF PHYSOSTIGMINE ON THE MECHANICAL AND ELECTRICAL RESPONSES OF THE CAT NICTATING MEMBRANE.

Authors: W C BOWMAN; B A CALLINGHAM; A W CUTHBERT
Journal: Br J Pharmacol Chemother Date: 1964-06

1 in total

Facilitation of neuromuscular transmission by anticholinesterase drugs.

1. Removal of acetylcholine from a limited volume by diffusion.

2. The interaction between benzoquinonium and anticholinesterases in skeletal muscle.

3. A comparison between the responses of avian and mammalian muscles to substances with facilitate neuromuscular transmission.

4. Neuromuscular facilitation and antidromic discharges in motor nerves: their relation to activity in motor nerve terminals.

5. Pharmacologic evidence for the existence of a presynaptic event in neuromuscular transmission.

6. The interaction of tensilon and neostigmine with acetylcholinesterase.

7. Action potentials of normal mammalian muscle. Effects of acetylcholine and eserine.

8. The actions of acetylcholine on denervated mammalian and frog's muscle.

9. The mechanism of anticurare action of certain neostigmine analogues.

10. Studies on the interrelationship of certain cholinergic compounds; the pharmacology of 3-acetoxy phenyltrimethylammonium methylsulfate.

1. THE EFFECTS OF PHYSOSTIGMINE ON THE MECHANICAL AND ELECTRICAL RESPONSES OF THE CAT NICTATING MEMBRANE.