Literature DB >> 1397062

Discrimination between two types of P2 purinoceptors by suramin in rat hepatocytes.

H Tomura1, F Okajima, Y Kondo.   

Abstract

Suramin, currently reported as a P2 purinoceptor antagonist, competitively inhibited P2 purinoceptor agonist-induced phospholipase C (PLC) stimulation, but not P2 purinoceptor agonist-induced adenylate cyclase (AC) inhibition in rat hepatocytes. Suramin did not inhibit vasopressin-induced PLC activity. We conclude that there are two types of P2 purinoceptors; one is suramin-sensitive and coupled to PLC in a stimulatory manner, and the other is suramin-insensitive and coupled to AC in an inhibitory manner.

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Year:  1992        PMID： 1397062     DOI： 10.1016/0922-4106(92)90054-y

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  ATP and endogenous agonists inhibit evoked [3H]-noradrenaline release in rat iris via A1 and P2y-like purinoceptors.

Authors:  H Fuder; U Muth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-10       Impact factor: 3.000

2.  P2-purinoceptor antagonists discriminate three contraction-mediating receptors for ATP in rat vas deferens.

Authors:  R Bültmann; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-01       Impact factor: 3.000

3.  The P(2)-purinoceptor antagonist suramin is a competitive antagonist at vasoactive intestinal peptide receptors in the rat gastric fundus.

Authors:  K M Jenkinson; J J Reid
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

4.  Regulation of cyclic AMP by extracellular ATP in cultured brain capillary endothelial cells.

Authors:  Z Anwar; J L Albert; S E Gubby; J P Boyle; J A Roberts; T E Webb; M R Boarder
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

5.  Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells.

Authors:  F Okajima; K Sato; H Tomura; A Kuwabara; H Nochi; K Tamoto; Y Kondo; Y Tokumitsu; M Ui
Journal:  Biochem J       Date:  1998-12-01       Impact factor: 3.857

Review 6.  Purinergic signalling in the liver in health and disease.

Authors:  Geoffrey Burnstock; Byron Vaughn; Simon C Robson
Journal:  Purinergic Signal       Date:  2013-11-24       Impact factor: 3.765
  6 in total

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