Literature DB >> 1397028

Decreased activity of rat A10 dopamine neurons following withdrawal from repeated cocaine.

J M Ackerman1, F J White.   

Abstract

Electrophysiological techniques were used to determine the basal activity of A10 dopamine (DA) neurons in the rat ventral tegmental area after a 10-14 day withdrawal from repeated cocaine treatment (10.0 mg/kg i.p. twice daily for 14 days). The number of spontaneously active A10 DA cells was significantly decreased (42%) in the cocaine-treated rats. This decreased activity may underlie the diminished basal levels of synaptic DA within the nucleus accumbens previously reported in cocaine-withdrawn rats and may account for anhedonia, anergia and cocaine craving reported by withdrawn cocaine addicts.

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Year:  1992        PMID： 1397028     DOI： 10.1016/0014-2999(92)90161-v

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

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5.  Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in cocaine dependence.

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8.  Repeated but Not Single Administration of Ketamine Prolongs Increases of the Firing Activity of Norepinephrine and Dopamine Neurons.

Authors:  Chidiebere M Iro; Rami Hamati; Mostafa El Mansari; Pierre Blier
Journal:  Int J Neuropsychopharmacol       Date:  2021-07-23       Impact factor: 5.176
  8 in total

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