Improvement in the efficacy of exercise first-pass radionuclide angiocardiography in detecting coronary artery disease and the effect of patient age.

The most widely used criterion of normality during exercise radionuclide angiocardiography (a five EF units increase in left ventricular ejection fraction from rest to exercise) has been established in young, healthy volunteers resulting in a relatively low specificity when applied to older, less fit patients or in women. In a group of 57 patients ranging in age from 22 to 79 years with a low likelihood of coronary artery disease, the age of the patient was the only independent variable predicting left ventricular ejection fraction change during exercise. The efficacy of a new age-based criterion for the diagnosis of coronary artery disease was then evaluated in 115 patients with chest pain undergoing both exercise first-pass radionuclide angiocardiography and coronary arteriography. Compared to the classic five EF unit criterion, the age-based criterion had a higher specificity (73.2% vs 34.1% P less than 0.001) without significant loss in sensitivity (85.1% vs 92.6%; P = NS).