Literature DB >> 1396586

Crystal structure of human platelet-derived growth factor BB.

C Oefner1, A D'Arcy, F K Winkler, B Eggimann, M Hosang.   

Abstract

The crystal structure of the homodimeric BB isoform of human recombinant platelet-derived growth factor (PDGF-BB) has been determined by X-ray analysis to 3.0 A resolution. The polypeptide chain is folded into two highly twisted antiparallel pairs of beta-strands and contains an unusual knotted arrangement of three intramolecular disulfide bonds. Dimerization leads to the clustering of three surface loops at each end of the elongated dimer, which most probably form the receptor recognition sites.

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Year:  1992        PMID： 1396586      PMCID： PMC556902          DOI： 10.1002/j.1460-2075.1992.tb05485.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  47 in total

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