Literature DB >> 13963921

A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine.

G C HOFFMAN, J S HEWLETT, F L GARZON.   

Abstract

A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis.

Entities:  

Keywords:  AGRANULOCYTOSIS; ANTIBODIES; ASTHMA; CHLORPROPAMIDE; DRUG ALLERGY

Mesh:

Substances:

Year:  1963        PMID: 13963921      PMCID: PMC480548          DOI: 10.1136/jcp.16.3.232

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN: 0021-9746            Impact factor:   3.411


  3 in total

1.  Leukocyte antibodies in human sera and in immune rabbit sera.

Authors:  R L WALFORD; E T PETERSON; P DOYLE
Journal:  Blood       Date:  1957-11       Impact factor: 22.113

2.  Studies on agranulocytosis. IV. Effects of chlorpromazine on nucleic acid synthesis of bone marrow cells in vitro.

Authors:  A V PISCIOTTA; J KALDAHL
Journal:  Blood       Date:  1962-09       Impact factor: 22.113

3.  Studies on agranulocytosis. III. The reduced glutathione (GSH) content of leukocytes of normals and patients recovered from agranulocytosis.

Authors:  A V PISCIOTTA; M DALY
Journal:  Blood       Date:  1960-11       Impact factor: 22.113

  3 in total

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