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Literature DB >> 13961468

Sympathetic vasodilatation in the rabbit ear.

Abstract

Changes in the blood content of a 1 cm(2) portion of the intact rabbit's ear were studied with transillumination and a photocell. Stimulation of the post-ganglionic sympathetic nerves produced a decrease in blood content, attributable to vasoconstriction, followed by an increased blood content, attributable to vasodilatation. The vasodilatation was enhanced by eserine and decreased by atropine. Guanethidine abolished the vasoconstriction but not the vasodilatation. After the ganglion had been decentralized by degeneration of the pre-ganglionic sympathetic nerves the vessels had an increased sensitivity to acetylcholine and the vasodilatation in response to sympathetic stimulation was enhanced. It is concluded that sympathetic stimulation results in the liberation of acetylcholine which causes vasodilatation.

Entities: Chemical Species

Keywords: ACETYLCHOLINE; GUANETHIDINE; PHYSOSTIGMINE; SYMPATHETIC NERVOUS SYSTEM; VASODILATOR AGENTS

Mesh：

Substances：

Year: 1962 PMID： 13961468 PMCID： PMC1482209 DOI： 10.1111/j.1476-5381.1962.tb01457.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

16 in total

2. Transmission from vasoconstrictor and vasodilator nerves to single smooth muscle cells of the guinea-pig uterine artery.

Authors: C Bell
Journal: J Physiol Date: 1969-12 Impact factor: 5.182

Sympathetic vasodilatation in the rabbit ear.

1. On the pharmacology of guanethidine.

2. The peripheral cardiovascular actions of guanethidine in dogs.

3. Sympathetic postganglionic cholinergic fibres.

4. Some observations on changes in the blood content of the cat's pancreas during activity.

5. Noradrenaline in artery walls and its dispersal by reserpine.

6. The use and limitations of atropine for pharmacological studies on autonomic effectors.

7. On the transmitter responsible for antidromic vasodilatation in the rabbit's ear.

8. Transmission failure in sympathetic nerves produced by hemicholinium.

9. Tissue amine levels and sympathetic blockade after guanethidine and bretylium.

10. Effect of guanethidine in revealing cholinergic sympathetic fibres.

1. The adrenergic mechanism in the nictitating membrane.

2. Transmission from vasoconstrictor and vasodilator nerves to single smooth muscle cells of the guinea-pig uterine artery.

3. Vascular lesions in rabbits infected with Trypanosoma (Trypanozoon) brucei.

4. Experimental autonomic neuropathy: an immunologically induced disorder of reflex vasomotor function.

5. A vasodilator innervation to the central artery of the rabbit ear.

6. Response to acetylcholine and nicotine of the perfused vessels of the rabbit ear.