Literature DB >> 13957287

A method for the quantitative estimation of drugs on the isolated intact trachea.

D JAMIESON.   

Abstract

A method is described for the detection and comparison of substances active on tracheal smooth muscle. Several pharmacological agents affecting smooth muscle have been tested using the technique. Sensitivity was high, results reproducible and linear log dose-response relationships obtained over a wide dosage range. The method has been used to estimate the concentrations of adrenaline, acetylcholine and histamine in test solutions of these compounds.

Entities:  

Keywords:  ACETYLCHOLINE; AMINOPHYLLINE; ATROPINE; BARIUM; CHLORIDES; EPINEPHRINE; HISTAMINE; SEROTONIN; TRACHEA

Mesh：

Substances：

Year:  1962        PMID： 13957287      PMCID： PMC1482150          DOI： 10.1111/j.1476-5381.1962.tb01190.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  4 in total

1.  An antagonism of 5-hydroxytryptamine by atropine.

Authors:  P A ROBERTSON
Journal:  J Physiol       Date:  1953-08       Impact factor: 5.182

2.  The action of antihistaminics and atropine in blocking the spasmogenic activity of serotonin on the guinea pig ileum.

Authors:  M M RAPPORT; G B KOELLE
Journal:  Arch Int Pharmacodyn Ther       Date:  1953-01

3.  [Simultaneous use of two methods to determine bronchial width and test bronchoactive substances].

Authors:  W GRAUBNER; G PETERS; H WICK
Journal:  Wien Klin Wochenschr       Date:  1952-08       Impact factor: 1.704

4.  A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine.

Authors:  H O Schild
Journal:  J Physiol       Date:  1942-06-02       Impact factor: 5.182
  4 in total
  6 in total

1.  Substance P as a potent stimulator of sneeze responses in experimental allergic rhinitis of guinea pigs.

Authors:  T Imamura; T Kambara
Journal:  Agents Actions       Date:  1992-11

Review 2.  The Schultz-Dale reaction: a review.

Authors:  N Chand; P Eyre
Journal:  Agents Actions       Date:  1978-04

3.  A pharmacological study of the toxin in a Cnidarian, Chironex fleckeri Southcott.

Authors:  S E Freeman; R J Turner
Journal:  Br J Pharmacol       Date:  1969-03       Impact factor: 8.739

4.  A method for recording smooth muscle and vascular responses of the blood-perfused dog trachea in situ.

Authors:  N Himori; N Taira
Journal:  Br J Pharmacol       Date:  1976-03       Impact factor: 8.739

5.  THE RESPONSES OF THE GUINEA-PIG ISOLATED INTACT TRACHEA TO TRANSMURAL STIMULATION AND THE RELEASE OF AN ACETYLCHOLINE-LIKE SUBSTANCE UNDER CONDITIONS OF REST AND STIMULATION.

Authors:  R F CARLYLE
Journal:  Br J Pharmacol Chemother       Date:  1964-02

6.  Mechanisms of intrinsic tone in bullfrog lung: relaxant effects of indomethacin, ouabain and potassium.

Authors:  H Downes; R A Edelstein; S M Taylor
Journal:  Br J Pharmacol       Date:  1986-03       Impact factor: 8.739
  6 in total

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