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Literature DB >> 13947829

Reduction of serum complement in rabbits after injection of endotoxin.

Abstract

Injection into rabbits of a consistently lethal dose of endotoxin regularly produced a rapid and sustained fall of complement levels and lowered the titers of antibody to endotoxin. Doses of endotoxin below the LD(50) lowered complement levels sporadically but not the titers of antibody to endotoxin. The possibility is discussed that complement may be involved in the mechanisms responsible for the lethal action of endotoxin.

Entities: Species

Keywords: COMPLEMENT; ENDOTOXINS

Mesh：

Substances：

Year: 1962 PMID： 13947829 PMCID： PMC2137625 DOI： 10.1084/jem.116.4.477

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

13 in total

1. Studies with radioactive endotoxin. I. The use of Cr51 to label endotoxin of Escherichia coli.

Authors: A I BRAUDE; F J CAREY; D SUTHERLAND; M ZALESKY
Journal: J Clin Invest Date: 1955-06 Impact factor: 14.808

2. Intradermal reactions in man to autologous erythrocytes sensitized with tuberculin or endotoxin.

Authors: S SELL; A I BRAUDE
Journal: J Immunol Date: 1961-08 Impact factor: 5.422

3. A comparison of shock due to endotoxin with anaphylactic shock.

Authors: M H WEIL; W W SPINK
Journal: J Lab Clin Med Date: 1957-10

4. Properdin system and immunity. II. Interaction of the properdin system with polysaccharides.

Authors: L PILLEMER; M D SCHOENBERG; L BLUM; L WURZ
Journal: Science Date: 1955-09-23 Impact factor: 47.728

5. The Influence of Endotoxin on Resistance to Infection.

Authors: A I Braude; J Siemienski
Journal: Bull N Y Acad Med Date: 1961-07

6. Preparation and biological properties of a chemically modified Escherichia coli endotoxin of high immunogenic potency and low toxicity.

Authors: H NOLL; A I BRAUDE
Journal: J Clin Invest Date: 1961-11 Impact factor: 14.808

7. Diagnostic complement fixation. I. A method.

Authors: A G OSLER; J H STRAUSS; M M MAYER
Journal: Am J Syph Gonorrhea Vener Dis Date: 1952-03

8. The susceptibility of mice to bacterial endotoxins.

Authors: R W SCHAEDLER; R J DUBOS
Journal: J Exp Med Date: 1961-03-01 Impact factor: 14.307

9. Studies on the mechanism of the Shwartzman phenomenon; similarities between reactions to endotoxins and certain reactions of bacterial allergy.

Authors: C A STETSON
Journal: J Exp Med Date: 1955-04-01 Impact factor: 14.307

10. A LABILE SERUM FACTOR IN EXPERIMENTAL ENDOTOXIN SHOCK: CROSS-TRANSFUSION STUDIES IN DOGS.

Authors: W W Spink; J Vick
Journal: J Exp Med Date: 1961-09-30 Impact factor: 14.307

26 in total

1. THE INITIAL STAGE OF CANINE ENDOTOXIN SHOCK AS AN EXPRESSION OF ANAPHYLACTIC SHOCK: STUDIES ON COMPLEMENT TITERS AND PLASMA HISTAMINE CONCENTRATIONS.

Authors: W W SPINK; R B DAVIS; R POTTER; S CHARTRAND
Journal: J Clin Invest Date: 1964-04 Impact factor: 14.808

Reduction of serum complement in rabbits after injection of endotoxin.

1. Studies with radioactive endotoxin. I. The use of Cr51 to label endotoxin of Escherichia coli.

2. Intradermal reactions in man to autologous erythrocytes sensitized with tuberculin or endotoxin.

3. A comparison of shock due to endotoxin with anaphylactic shock.

4. Properdin system and immunity. II. Interaction of the properdin system with polysaccharides.

5. The Influence of Endotoxin on Resistance to Infection.

6. Preparation and biological properties of a chemically modified Escherichia coli endotoxin of high immunogenic potency and low toxicity.

7. Diagnostic complement fixation. I. A method.

8. The susceptibility of mice to bacterial endotoxins.

9. Studies on the mechanism of the Shwartzman phenomenon; similarities between reactions to endotoxins and certain reactions of bacterial allergy.

10. A LABILE SERUM FACTOR IN EXPERIMENTAL ENDOTOXIN SHOCK: CROSS-TRANSFUSION STUDIES IN DOGS.

1. THE INITIAL STAGE OF CANINE ENDOTOXIN SHOCK AS AN EXPRESSION OF ANAPHYLACTIC SHOCK: STUDIES ON COMPLEMENT TITERS AND PLASMA HISTAMINE CONCENTRATIONS.

2. RELATIONSHIP BETWEEN PARTICLE SIZE AND BIOLOGICAL ACTIVITY OF E. COLI BOIVIN ENDOTOXIN.

3. MECHANISMS OF ENDOTOXIN TOLERANCE. 3. THE REFRACTORY STATE DURING CONTINUOUS INTRAVENOUS INFUSIONS OF ENDOTOXIN.

4. Role of complement in lethal bacterial lipopolysaccharide-induced hypotensive and coagulative changes.

5. Endotoxin tolerance diminishes certain antiinflammatory effects of endotoxin.

Review 6. The effects of bacterial endotoxins on host mediation systems. A review.

7. Interactions of the complement system with native and chemically modified endotoxins.

8. Consumptive opsoninopathy: possible pathogenesis in lethal and opportunistic infections.

9. Experimental production of lethal Escherichia coli bacteremia of pelvic origin.

10. Interaction of lipopolysaccharides and lipid A with complement in rats and its relation to endotoxicity.