Literature DB >> 1394660

New antitumor bicyclic hexapeptides, RA-XI, -XII, -XIII and -XIV from Rubia cordifolia.

H Morita1, T Yamamiya, K Takeya, H Itokawa.   

Abstract

Four new bicyclic hexapeptides, named as RA-XI, -XII, XIII and -XIV were isolated from Rubia cordifolia and showed potent antitumor activities against P-388. The structures were elucidated from spectroscopic and chemical evidences. RA-XII, XIII and -XIV were proved to be unique bicyclic hexapeptidic glucosides.

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Year:  1992        PMID： 1394660     DOI： 10.1248/cpb.40.1352

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  7 in total

1.  Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N9-Methyl Group in the Conformation and Bioactivity.

Authors:  Zhe Wang; Si-Meng Zhao; Li-Mei Zhao; Xiao-Qiang Chen; Guang-Zhi Zeng; Ning-Hua Tan
Journal:  PLoS One       Date:  2015-12-22       Impact factor: 3.240

2.  Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.

Authors:  Lihua Song; Zhe Wang; Yurong Wang; Di Guo; Jianhong Yang; Lijuan Chen; Ninghua Tan
Journal:  Molecules       Date:  2017-11-11       Impact factor: 4.411

Review 3.  A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers.

Authors:  Hailemeleak Regassa; Anuradha Sourirajan; Vikas Kumar; Sadanand Pandey; Deepak Kumar; Kamal Dev
Journal:  Cancers (Basel)       Date:  2022-08-12       Impact factor: 6.575

Review 4.  A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications.

Authors:  Min Wen; Qi Chen; Wang Chen; Jing Yang; Xiaogang Zhou; Chunxiang Zhang; Anguo Wu; Jia Lai; Jianping Chen; Qibing Mei; Shuo Yang; Cai Lan; Jianming Wu; Feihong Huang; Long Wang
Journal:  Front Pharmacol       Date:  2022-09-09       Impact factor: 5.988

5.  Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia.

Authors:  Kuo Xu; Penglong Wang; Bin Yuan; Yatao Cheng; Qiang Li; Haimin Lei
Journal:  Chem Cent J       Date:  2013-05-04       Impact factor: 4.215

6.  RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation.

Authors:  Hoi-Wing Leung; Si-Meng Zhao; Grace Gar-Lee Yue; Julia Kin-Ming Lee; Kwok-Pui Fung; Ping-Chung Leung; Ning-Hua Tan; Clara Bik-San Lau
Journal:  Sci Rep       Date:  2015-11-23       Impact factor: 4.379

7.  Hyaluronic Acid Coated Liposomes Co-Delivery of Natural Cyclic Peptide RA-XII and Mitochondrial Targeted Photosensitizer for Highly Selective Precise Combined Treatment of Colon Cancer.

Authors:  Yanqing Xu; Yongrong Yao; Linxiao Wang; Huachao Chen; Ninghua Tan
Journal:  Int J Nanomedicine       Date:  2021-07-22
  7 in total

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