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Literature DB >> 1394627

Isolation and structures of antibacterial binaphtho-alpha-pyrones, talaroderxines A and B, from Talaromyces derxii.

K Suzuki¹, K Nozawa, S Nakajima, S Udagawa, K Kawai.

Abstract

New compounds designated talaroderxines A (1) and B (2) were isolated from a new heterothallic ascomycetous fungus, Talaromyces derxii, cultivated on rice. The structures of 1a and 1b were elucidated by means of spectroscopic examination and chemical reactions. Talaroderxines A (1a) and B (1b) are atropisomers of a 6,6'-binaphtho-alpha-pyrone derivative, and have strong antibacterial activity against Bacillus subtilis.

Entities: Chemical Species

Mesh：

Substances：
Pyrones

Year: 1992 PMID： 1394627 DOI： 10.1248/cpb.40.1116

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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Cited

9 in total

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Isolation and structures of antibacterial binaphtho-alpha-pyrones, talaroderxines A and B, from Talaromyces derxii.

1. Synthesis of (-)-viriditoxin: a 6,6'-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ.

2. Polyphasic taxonomy of the genus Talaromyces.

3. Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.

4. Mycopyranone: a 8,8'-binaphthopyranone with potent anti-MRSA activity from the fungus Phialemoniopsis sp.

5. Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus.

6. Synthesis of 6,6'-binaphthopyran-2-one natural products: pigmentosin A, talaroderxines A and B.

7. Second-Generation Synthesis of (-)-Viriditoxin.

8. The Bioactive Secondary Metabolites from Talaromyces species.

9. Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources.