| Literature DB >> 13940786 |
Z OVARY, B BENACERRAF, K J BLOCH.
Abstract
Guinea pig 7Sgamma(1) antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sgamma(2) antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sgamma(2) antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites.Entities:
Keywords: ANAPHYLAXIS; ANTIBODIES; GAMMA GLOBULIN
Mesh:
Substances:
Year: 1963 PMID: 13940786 PMCID: PMC2137601 DOI: 10.1084/jem.117.6.951
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307