Literature DB >> 13940785

Passive cutaneous anaphylaxis with antibody fragments.

Z OVARY, A TARANTA.   

Abstract

Pepsin-digested rabbit antibody (5S) provoked reverse passive cutaneous anaphylaxis in the guinea pig, but was somewhat less effective, mole for mole, than the native antibody. Fixation of guinea pig complement by the pepsin-digested antibody could not be demonstrated either in vitro or in vivo. Splitting of the 5S fragment into two monovalent fragments (3.5S) markedly reduced the capacity to provoke reverse passive cutaneous anaphylaxis.

Entities:  

Keywords:  ANAPHYLAXIS; ANTIGEN-ANTIBODY REACTIONS

Mesh：

Substances：

Year:  1963        PMID： 13940785     DOI： 10.1126/science.140.3563.193

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  ON THE SENSITIZING PROPERTIES OF SOME NORMAL AND PATHOLOGIC HUMAN IMMUNE GLOBULINS AND FRAGMENTS OBTAINED BY PAPAIN OF PEPSIN DIGESTION.

Authors:  E C FRANKLIN; Z OVARY
Journal:  Immunology       Date:  1963-09       Impact factor: 7.397

2.  Haemorrhagic reactions elicited at sites of passive cutaneous anaphylaxis by the intravenous injection of aggregated gamma-globulin.

Authors:  O G Bier; H C Passos; M Siqueira
Journal:  Immunology       Date:  1968-02       Impact factor: 7.397

3.  Stepwise cleavage of rabbit immunoglobulin G by papain and isolation of four types of biologically active Fc fragments.

Authors:  S Utsumi
Journal:  Biochem J       Date:  1969-04       Impact factor: 3.857

4.  Properties of antibodies cytophilic for macrophages.

Authors:  A Berken; B Benacerraf
Journal:  J Exp Med       Date:  1966-01-01       Impact factor: 14.307

5.  Complement fixation by the F(ab')2-fragment of pepsin-treated rabbit antibody.

Authors:  K B Reid
Journal:  Immunology       Date:  1971-05       Impact factor: 7.397

6.  SPECIFIC FRACTIONATION OF HUMAN ANTIDEXTRAN ANTIBODIES. II. ASSAY OF HUMAN ANTIDEXTRAN SERA AND SPECIFICALLY FRACTIONATED PURIFIED ANTIBODIES BY MICROCOMPLEMENT FIXATION AND COMPLEMENT FIXATION INHIBITION TECHNIQUES.

Authors:  J GELZER; E A KABAT
Journal:  J Exp Med       Date:  1964-01-01       Impact factor: 14.307

7.  Specificity of fixation loci for homocytotropic antibodies.

Authors:  J R Battisto; D Budman; R Freedman
Journal:  J Exp Med       Date:  1971-08-01       Impact factor: 14.307

8.  PEPSIN DIGESTION OF RABBIT AND SHEEP ANTIBODIES. THE EFFECT ON COMPLEMENT FIXATION.

Authors:  P H SCHUR; E L BECKER
Journal:  J Exp Med       Date:  1963-12-01       Impact factor: 14.307
  8 in total

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