BACKGROUND: The development of a wound infection has been identified as a favorable prognostic factor after oncologic surgical procedures. METHODS: The authors retrospectively studied the relationship between postoperative wound infection, local/regional tumor recurrence, and survival rates in 134 patients undergoing therapeutic surgical resection for squamous cell carcinoma of the head and neck (SCCHN). RESULTS: The median age was 61 years (range, 25-87 years) with most (75%) patients having advanced disease (Stage III or IV). Patients without evidence of recurrent disease were followed up for a median time of 34 months (range, 24-68 months). Twenty-nine (22%) had local or regional bacterial infections develop postoperatively. Recurrence rates were increased (P = 0.008) in patients with postoperative wound infections compared with patients who had distant infections, e.g., pneumonia or urinary tract infection, or no infection. Disease-free survival also was adversely affected (P = 0.04) in this group. Both advanced tumor stage and postoperative wound infections were independently associated with decreased survival, with odds ratios of 2:3 and 2:4, respectively. CONCLUSIONS: These data contrast with other reports in the literature of a beneficial effect of postoperative wound infection on outcome. These findings suggest a possible relationship between local/regional immune function and postoperative infection in patients with SCCHN:
BACKGROUND: The development of a wound infection has been identified as a favorable prognostic factor after oncologic surgical procedures. METHODS: The authors retrospectively studied the relationship between postoperative wound infection, local/regional tumor recurrence, and survival rates in 134 patients undergoing therapeutic surgical resection for squamous cell carcinoma of the head and neck (SCCHN). RESULTS: The median age was 61 years (range, 25-87 years) with most (75%) patients having advanced disease (Stage III or IV). Patients without evidence of recurrent disease were followed up for a median time of 34 months (range, 24-68 months). Twenty-nine (22%) had local or regional bacterial infections develop postoperatively. Recurrence rates were increased (P = 0.008) in patients with postoperative wound infections compared with patients who had distant infections, e.g., pneumonia or urinary tract infection, or no infection. Disease-free survival also was adversely affected (P = 0.04) in this group. Both advanced tumor stage and postoperative wound infections were independently associated with decreased survival, with odds ratios of 2:3 and 2:4, respectively. CONCLUSIONS: These data contrast with other reports in the literature of a beneficial effect of postoperative wound infection on outcome. These findings suggest a possible relationship between local/regional immune function and postoperative infection in patients with SCCHN:
Authors: William Scotton; Richard Cobb; Leo Pang; Iain Nixon; Anil Joshi; Jeanne-Pierre Jeannon; Richard Oakley; Gary French; Carolyn Hemsley; Ricard Simo Journal: Eur Arch Otorhinolaryngol Date: 2012-01-25 Impact factor: 2.503
Authors: Ingrid Stelzmueller; Matthias Zitt; Felix Aigner; Reinhold Kafka-Ritsch; Robert Jäger; Alexander De Vries; Peter Lukas; Wolfgang Eisterer; Hugo Bonatti; Dietmar Ofner Journal: J Gastrointest Surg Date: 2008-12-11 Impact factor: 3.452
Authors: Janne H Hammer; Tommie Mynster; Solveig Rosendahl; Claus M Reimert; Nils Brünner; Flemming Skov; Hans J Nielsen Journal: Int J Gastrointest Cancer Date: 2002
Authors: Nicolas Penel; Charles Fournier; Micheline Roussel-Delvallez; Danièle Lefebvre; Ahmed Kara; Yann Mallet; Jean-Charles Neu; Jean-Louis Lefebvre Journal: Support Care Cancer Date: 2004-09 Impact factor: 3.603