| Literature DB >> 1393556 |
T Yoneda1, S Inagaki, Y Hayashi, T Nomura, H Takagi.
Abstract
The effects of unilateral nerve transection on manganese and copper/zinc superoxide dismutase (Mn-SOD and Cu/Zn-SOD) mRNA levels in the facial nucleus were studied by in situ hybridization. An increase of Mn-SOD mRNA levels was first seen in the ipsilateral facial nucleus 12 h after axotomy, and was most pronounced at 4-7 days after this procedure; by 56 days, the increase disappeared. There was no change in Cu/Zn-SOD mRNA levels at any time after axotomy. We further confirmed, by immunohistochemistry, that the increase in Mn-SOD transcription was followed by protein synthesis. These results are suggestive of an important role for Mn-SOD in defense, regeneration and recovery responses following nerve transection.Entities:
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Year: 1992 PMID： 1393556 DOI： 10.1016/0006-8993(92)90153-z
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252