Literature DB >> 13935174

Effect of teratogenic and related dyes on the haemoglobin nitrite sensitivity reaction.

W K METCALF.   

Abstract

The teratogenic dyes trypan blue and Evans blue have a marked and immediate action on the oxidation stability of intracellular haemoglobin in rats. Of the proved non-teratogenic substances tested only o-tolidine has an effect on the haemoglobin stability, and this effect is slow. It is suggested that the effect of the teratogens on the haemoglobin oxidation sensitivity is due to interference with the protein component of the flavoprotein enzymes.

Entities:  

Keywords:  DYES; HEMOGLOBIN; NITRITES; RIBOFLAVIN; TRYPAN BLUE

Mesh：

Substances：

Year:  1962        PMID： 13935174      PMCID： PMC1482216          DOI： 10.1111/j.1476-5381.1962.tb01453.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  6 in total

1.  Studies on the mechanism of teratogenic action of trypan blue.

Authors:  J G WILSON; A R BEAUDOIN; H J FREE
Journal:  Anat Rec       Date:  1959-02

2.  Inhibition of enzymes by Atebrin.

Authors:  H C HEMKER; W C HUELSMANN
Journal:  Biochim Biophys Acta       Date:  1960-10-21

3.  Effect of trypan blue on rat embryos.

Authors:  F BECK; B SPENCER; J S BAXTER
Journal:  Nature       Date:  1960-08-13       Impact factor: 49.962

4.  Teratogenic effect of trypan blue on the developing chick.

Authors:  A R BEAUDOIN; J G WILSON
Journal:  Proc Soc Exp Biol Med       Date:  1958-01

5.  Dose effect curve of somatic mutations in Ephestia kuhniella Z, for low dose-range (0-200 r.).

Authors:  I MUELLER; E A LOEBBECKE; O OLTMANNS
Journal:  Nature       Date:  1962-05-26       Impact factor: 49.962

6.  The sensitivity of intracorpuscular haemoglobin to oxidation by nitrite ions. I. The effect of growth, starvation and diet.

Authors:  W K METCALF
Journal:  Phys Med Biol       Date:  1962-01       Impact factor: 3.609
  6 in total

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