Allergic encephalomyelitis: rapid induction without the aid of adjuvants.

Rapid production of allergic encephalomyelitis has heretofore required injection of nervous tissue emulsified in immunologic adjuvants. Adjuvants are not required if large doses of a potent nervous-tissue anttigen and a highly susceptible strain of rats are used. Susceptibility was increased in animals inoculated beforehand with pertussis vaccine.