OBJECTIVE: To examine the significance of fetal nuchal translucency at 10-14 weeks' gestation in the prediction of abnormal fetal karyotype. DESIGN: Prospective screening study. SETTING: The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London. SUBJECTS: 827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling. MAIN OUTCOME MEASURE: Incidence of chromosomal defects. RESULTS: The incidence of chromosomal defects was 3% (28 of 827 cases). In the 51 (6%) fetuses with nuchal translucency 3-8 mm thick the incidence of chromosomal defects was 35% (18 cases). In contrast, only 10 of the remaining 776 (1%) fetuses were chromosomally abnormal. CONCLUSION: Fetal nuchal translucency > or = 3 mm is a useful first trimester marker for fetal chromosomal abnormalities.
OBJECTIVE: To examine the significance of fetal nuchal translucency at 10-14 weeks' gestation in the prediction of abnormal fetal karyotype. DESIGN: Prospective screening study. SETTING: The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London. SUBJECTS: 827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling. MAIN OUTCOME MEASURE: Incidence of chromosomal defects. RESULTS: The incidence of chromosomal defects was 3% (28 of 827 cases). In the 51 (6%) fetuses with nuchal translucency 3-8 mm thick the incidence of chromosomal defects was 35% (18 cases). In contrast, only 10 of the remaining 776 (1%) fetuses were chromosomally abnormal. CONCLUSION: Fetal nuchal translucency > or = 3 mm is a useful first trimester marker for fetal chromosomal abnormalities.
Authors: K H Nicolaides; C H Rodeck; I Lange; J Watson; C M Gosden; D Miller; R S Mibashan; C Moniz; P Morgan-Capner; S Campbell Journal: Br J Obstet Gynaecol Date: 1985-07
Authors: M T Cullen; S Gabrielli; J J Green; N Rizzo; M J Mahoney; C Salafia; L Bovicelli; J C Hobbins Journal: Prenat Diagn Date: 1990-10 Impact factor: 3.050
Authors: J C Pons; A A Diallo; P Eydoux; S Rais; S Doumerc; R Frydman; E Papiernik Journal: Eur J Obstet Gynecol Reprod Biol Date: 1989-11 Impact factor: 2.435