Literature DB >> 1392538

Liposomes as a drug delivery system for antisense oligonucleotides.

R L Juliano1, S Akhtar.   

Abstract

Antisense oligonucleotides seem to provide a promising new tool for the therapy of viral diseases and of cancer. However, before the therapeutic potential of antisense compounds can be fulfilled, it will be necessary to overcome significant problems relating to their inefficient uptake by cells and their rapid loss from the body. Phospholipid vesicles (liposomes) have been widely used as a drug delivery system for standard anticancer and anti-infectious drugs. In this article we examine the potential role of liposomes as a drug delivery system for antisense oligonucleotides.

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Year:  1992        PMID： 1392538     DOI： 10.1089/ard.1992.2.165

Source DB:  PubMed          Journal:  Antisense Res Dev        ISSN： 1050-5261


  20 in total

1.  Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers.

Authors:  H Yoo; R L Juliano
Journal:  Nucleic Acids Res       Date:  2000-11-01       Impact factor: 16.971

2.  The spherulites(TM): a promising carrier for oligonucleotide delivery.

Authors:  N Mignet; A Brun; C Degert; B Delord; D Roux; C Hélène; R Laversanne; J C François
Journal:  Nucleic Acids Res       Date:  2000-08-15       Impact factor: 16.971

3.  Modulation of human interferon-gamma biosynthesis by antisense oligodeoxynucleotides.

Authors:  C M Boeve; M De Ley
Journal:  Mol Biotechnol       Date:  2000-02       Impact factor: 2.695

4.  Characterization of a synthetic anionic vector for oligonucleotide delivery using in vivo whole body dynamic imaging.

Authors:  Bertrand Tavitian; Stéphane Marzabal; Valérie Boutet; Bertrand Kühnast; Salvatore Terrazzino; Marinette Moynier; Frédéric Dollé; Jean Robert Deverre; Alain R Thierry
Journal:  Pharm Res       Date:  2002-04       Impact factor: 4.200

Review 5.  Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects.

Authors:  R A Stull; F C Szoka
Journal:  Pharm Res       Date:  1995-04       Impact factor: 4.200

6.  Radiolabeled oligonucleotides for antisense imaging.

Authors:  Arun K Iyer; Jiang He
Journal:  Curr Org Synth       Date:  2011-08-01       Impact factor: 1.975

7.  PAMAM dendrimers as delivery agents for antisense oligonucleotides.

Authors:  H Yoo; P Sazani; R L Juliano
Journal:  Pharm Res       Date:  1999-12       Impact factor: 4.200

8.  Synthesis and hybridization properties of oligonucleotides containing 2'-O-modified ribonucleotides.

Authors:  T H Keller; R Häner
Journal:  Nucleic Acids Res       Date:  1993-09-25       Impact factor: 16.971

9.  Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay.

Authors:  J P Vaughn; J D Iglehart; S Demirdji; P Davis; L E Babiss; M H Caruthers; J R Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-29       Impact factor: 11.205

10.  Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor.

Authors:  Andrew J Hollins; Mustapha Benboubetra; Yadollah Omidi; Bernd H Zinselmeyer; Andreas G Schatzlein; Ijeoma F Uchegbu; Saghir Akhtar
Journal:  Pharm Res       Date:  2004-03       Impact factor: 4.200
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