Literature DB >> 1392441

Association between serum-soluble CD8 levels and parameters of immune activation in patients with human immunodeficiency virus infection.

G P Tilz1, R Zangerle, G Weiss, P Fritsch, H Wachter, D Fuchs.   

Abstract

We compared the serum concentrations of soluble CD8 with the immune activation markers neopterin, interferon-gamma, tumour necrosis factor-alpha, soluble CD4, and with CD4+ and CD8+ T-cell counts in patients with human immunodeficiency virus (HIV) infection. The majority of patients had increased concentrations of soluble CD8, interferon-gamma and neopterin, and various significant correlations existed between them. Our results support the view that enhanced soluble CD8 levels indicate activated CD8+ T cells in patients with HIV infection.

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Year:  1992        PMID： 1392441     DOI： 10.1007/bf00180281

Source DB:  PubMed          Journal:  Clin Investig        ISSN： 0941-0198


  13 in total

Review 1.  Neopterin as marker for activation of cellular immunity: immunologic basis and clinical application.

Authors:  H Wachter; D Fuchs; A Hausen; G Reibnegger; E R Werner
Journal:  Adv Clin Chem       Date:  1989       Impact factor: 5.394

2.  Optimal collection of blood samples for the measurement of tumor necrosis factor alpha.

Authors:  A R Exley; J Cohen
Journal:  Cytokine       Date:  1990-09       Impact factor: 3.861

3.  Soluble CD8 during T cell activation.

Authors:  B E Tomkinson; M C Brown; S H Ip; S Carrabis; J L Sullivan
Journal:  J Immunol       Date:  1989-04-01       Impact factor: 5.422

4.  Neopterin as a predictive marker for disease progression in human immunodeficiency virus type 1 infection.

Authors:  D Fuchs; T J Spira; A Hausen; G Reibnegger; E R Werner; G W Felmayer; H Wachter
Journal:  Clin Chem       Date:  1989-08       Impact factor: 8.327

Review 5.  Immunopathogenic mechanisms of HIV infection: cytokine induction of HIV expression.

Authors:  Z F Rosenberg; A S Fauci
Journal:  Immunol Today       Date:  1990-05

6.  Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome.

Authors:  J Lähdevirta; C P Maury; A M Teppo; H Repo
Journal:  Am J Med       Date:  1988-09       Impact factor: 4.965

7.  Serum soluble CD8 molecule is a marker of CD8 T-cell activation in HIV-1 disease.

Authors:  P Nishanian; B Hofmann; Y Wang; A L Jackson; R Detels; J L Fahey
Journal:  AIDS       Date:  1991-07       Impact factor: 4.177

8.  Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.

Authors:  D Fuchs; A Hausen; G Reibnegger; E R Werner; G Werner-Felmayer; M P Dierich; H Wachter
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1989

9.  The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1.

Authors:  J L Fahey; J M Taylor; R Detels; B Hofmann; R Melmed; P Nishanian; J V Giorgi
Journal:  N Engl J Med       Date:  1990-01-18       Impact factor: 91.245

10.  Shedding of the soluble form of the CD8 complex by CD8+/HLA-DR+ cells in HIV-1-infected patients.

Authors:  C Agostini; G Pizzolo; R Zambello; L Trentin; F Siviero; F Vinante; L Morosato; E Francavilla; P Cadrobbi; G Semenzato
Journal:  AIDS       Date:  1991-07       Impact factor: 4.177
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