Glucose uptake and dissimilation by x-irradiated, starved, and division-inhibited yeast.

Spoerl, Edward (U. S. Army Medical Research Laboratory, Fort Knox, Ky.) and C. W. Quiner. Glucose uptake and dissimilation by X-irradiated, starved, and division-inhibited yeast. J. Bacteriol. 82:764-769. 1961.-Estimates of the relative participation of the pentose cycle and the Embden-Meyerhof-Parnas pathways in sugar dissimilation, by means of C(14)O(2) recoveries from yeast cells fed specifically labeled glucose, showed significant differences indicating less pentose cycle activity in starved irradiated cells than in unirradiated cells. This result is in qualitative agreement with previously observed respiratory quotient values, which indicated greater glycolytic activity in starved irradiated cells; this implicates a change in pathways of dissimilation in the responses observed following irradiation and starvation. A concurrent lower rate of uptake of glucose from the medium was observed for unirradiated, starved cells as compared to irradiated cells. The possibility that the membrane is the site of the cellular change involved in these responses is discussed.