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Literature DB >> 139132

Relationship of antibody affinity to onset of immune complex disease in New Zealand mice.

Abstract

Affinity (KR) of antibody to human serum transferrin in New Zealand mice was measured by a globulin precipitation technique. KR was low in mice immunized early in life, increased with age of immunization up to 16-26 weeks, and then fell to low levels. KR in young and old NZB mice was increased by immunization with antigen in Freund's complete adjuvant. The correlation between low affinity antibody production and susceptibility to immune complex disease is discussed.

Entities: Gene Species

Mesh：

Substances：

Year: 1977 PMID： 139132 PMCID： PMC1006627 DOI： 10.1136/ard.36.1.39

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

26 in total

1. RENAL IMMUNOFLUORESCENCE IN NZB-NZW MICE.

Authors: I AARONS
Journal: Nature Date: 1964-09-05 Impact factor: 49.962

2. Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice.

Authors: B J HELYER; J B HOWIE
Journal: Nature Date: 1963-01-12 Impact factor: 49.962

3. Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.

Authors: J F Bach; M Dardenne; J C Salomon
Journal: Clin Exp Immunol Date: 1973-06 Impact factor: 4.330

4. Relative affinity of anti-protein antibodies in New Zealand mice.

Authors: R E Petty; M W Steward
Journal: Clin Exp Immunol Date: 1972-11 Impact factor: 4.330

Review 5. Immunopathology and neoplasms in New Zealand black (NZB) and SJL-J mice.

Authors: J East
Journal: Prog Exp Tumor Res Date: 1970

6. The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice.

Authors: M W Steward; F E Katz; N J West
Journal: Clin Exp Immunol Date: 1975-07 Impact factor: 4.330

10. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.

Authors: M B Oldstone; F J Dixon
Journal: J Exp Med Date: 1969-03-01 Impact factor: 14.307

1 in total

1. Anti-deoxyribonucleic acid antibody associated with persistent infection of mink with Aleutian disease virus.

Authors: E C Hahn; A J Kenyon
Journal: Infect Immun Date: 1980-08 Impact factor: 3.441