Literature DB >> 13906

Inhibition of gastric secretion in treatment of pancreatic insufficiency.

J H Saunders, S Drummond, K G Wormsley.   

Abstract

The content of pancreatic enzymes in the duodenum was studied in two patients with pancreatic achylia after a standard meal supplemented with commercial pancreatic extract. Gastric transit of the enzymes, with appearance of near-normal amounts in the duodenal contents, occurred only after inhibition of gastric secretion and buffering of residual gastric acid with antacids. Gastric inhibition and neutralisation of acid are therefore necessary for the satisfactory treatment of patients with pancreatic exocrine insufficiency but normal gastric function.

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Year:  1977        PMID： 13906      PMCID： PMC1604831          DOI： 10.1136/bmj.1.6058.418

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  8 in total

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Journal:  Gut       Date:  1963-09       Impact factor: 23.059

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Journal:  Arch Mal Appar Dig Mal Nutr       Date:  1960-06

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Review 6.  Pancreatic extracts in the treatment of pancreatic exocrine insufficiency.

Authors:  J H Saunders; K G Wormsley
Journal:  Gut       Date:  1975-02       Impact factor: 23.059

7.  The response to infusion of a combination of secretin and pancreozymin in health and disease.

Authors:  K G Wormsley
Journal:  Scand J Gastroenterol       Date:  1969       Impact factor: 2.423

8.  Effects of long-term treatment with metiamide.

Authors:  B Thjodleifsson; K G Wormsley
Journal:  Digestion       Date:  1975       Impact factor: 3.216
  8 in total
  7 in total

Review 1.  Surgery for pancreatic cancer.

Authors:  D C Carter
Journal:  Br Med J       Date:  1980-03-15

Review 2.  Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 2. Tests of pancreatic secretion.

Authors:  E J Boyd; K G Wormsley
Journal:  Int J Pancreatol       Date:  1987-08

3.  Non-ulcer users of cimetidine.

Authors: 
Journal:  Br Med J (Clin Res Ed)       Date:  1981-07-11

4.  Pancreatic enzyme replacement therapy. Importance of gastric acid secretion, H2-antagonists, and enteric coating.

Authors:  F Marotta; S J O'Keefe; I N Marks; A Girdwood; G Young
Journal:  Dig Dis Sci       Date:  1989-03       Impact factor: 3.199

5.  Effect of intrajejunal acidity on aqueous phase bile acid and lipid concentrations in pancreatic steatorrhoea due to cystic fibrosis.

Authors:  P L Zentler-Munro; W J Fitzpatrick; J C Batten; T C Northfield
Journal:  Gut       Date:  1984-05       Impact factor: 23.059

6.  Effect of cimetidine on enzyme inactivation, bile acid precipitation, and lipid solubilisation in pancreatic steatorrhoea due to cystic fibrosis.

Authors:  P L Zentler-Munro; D R Fine; J C Batten; T C Northfield
Journal:  Gut       Date:  1985-09       Impact factor: 23.059

7.  Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis.

Authors:  Devi Mukkai Krishnamurty; Atoosa Rabiee; Sanjay B Jagannath; Dana K Andersen
Journal:  Ther Clin Risk Manag       Date:  2009-07-12       Impact factor: 2.423
  7 in total

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