Antigenic studies of Candida. II. Antigenic relation of Candida albicans group A and group B to Candida stellatoidea and Candida tropicalis.

Hasenclever, H. F. (U. S. Public Health Service, Bethesda, Md.), William O. Mitchell, and Joseph Loewe. Antigenic studies of Candida. II. Antigenic relation of Candida albicans group A and group B to Candida stellatoidea and Candida tropicalis. J. Bacteriol. 82:574-577. 1961.-Previous work in our laboratory has shown the presence of two antigenic groups within the species Candida albicans. These groups have been designated as groups A and B. Subsequent studies have been conducted to show the antigenic relationship of these groups with Candida stellatoidea and Candida tropicalis. Antisera to two strains each of C. albicans group A, C. albicans group B, C. stellatoidea, and C. tropicalis were used in this investigation. Individual suspensions from each of nine strains of C. stellatoidea and from ten strains each of the other groups and species were used to test the agglutinative properties of unadsorbed and adsorbed antisera. Separate samples of antisera to each immunizing strain were reciprocally cross adsorbed with the other immunizing strains and tested for agglutination. The results indicated that C. albicans group A and C. tropicalis were antigenically identical and C. albicans group B and C. stellatoidea were antigenically indistinguishable.