Literature DB >> 1390174

Granulomatous hypersensitivity to protamine as a complication of insulin therapy.

M M Hulshof1, W R Faber, W F Kniestedt, M J Boeree, P Kreek.   

Abstract

A patient is described who developed a granulomatous skin reaction to injections of protamine-insulin for the treatment of her diabetes mellitus. By means of skin testing it was shown that this reaction was caused by protamine. No adverse effects were seen when she was injected with insulin which did not contain protamine.

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Year:  1992        PMID: 1390174     DOI: 10.1111/j.1365-2133.1992.tb00130.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN: 0007-0963            Impact factor:   9.302


  3 in total

1.  Case files of the Harvard Medical Toxicology Fellowship at Children's Hospital Boston: an insulin overdose.

Authors:  Aaron Benjamin Skolnik; Michele Burns Ewald
Journal:  J Med Toxicol       Date:  2010-12

Review 2.  Place of excipients in drug-related allergy.

Authors:  A Barbaud
Journal:  Clin Rev Allergy Immunol       Date:  1995       Impact factor: 8.667

3.  Successful desensitization with human insulin in a patient with an insulin allergy and hypersensitivity to protamine: a case report.

Authors:  Claudia Pföhler; Cornelia Sl Müller; Dirk O Hasselmann; Wolfgang Tilgen
Journal:  J Med Case Rep       Date:  2008-08-26
  3 in total

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