Literature DB >> 1389954

Diffusion of cloxacillin into synovial tissue.

H Mattie1, S De Marie, G Slaghuis, P M Rozing, E Van Strijen.   

Abstract

After a 30 min i.v. infusion of 1 g cloxacillin, the concentrations of this antibiotic were measured in plasma and synovial tissue samples from 11 patients undergoing total hip replacement. Assuming passive distribution between plasma and tissue the rate constants of distribution were estimated. The mean half-life of distribution was 22 min. The concentration of free drug in synovial tissue was estimated to be 77% of the total tissue concentration. The maximum tissue drug concentration after an i.v. bolus dose is predicted to occur at about 37 min.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1389954      PMCID： PMC1381402          DOI： 10.1111/j.1365-2125.1992.tb04138.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  5 in total

Review 1.  The importance of tissue antibiotic activity in the prevention of operative wound infection.

Authors:  T M Bergamini; H C Polk
Journal:  J Antimicrob Chemother       Date:  1989-03       Impact factor: 5.790

2.  Evaluation of cloxacillin concentrations in plasma and muscle tissue during cardiopulmonary bypass.

Authors:  B J Kullberg; H Mattie; H A Huysmans; R van Furth
Journal:  Scand J Infect Dis       Date:  1991

3.  The relation between plasma and tissue concentrations of antibiotics. Description of a method.

Authors:  H Mattie; J J Hoogeterp; J Hermans
Journal:  J Pharmacokinet Biopharm       Date:  1987-04

4.  The penetration of erythromycin into human bronchial mucosa.

Authors:  H Mattie; J J Hoogeterp; J P Kaajan; J Hermans
Journal:  Br J Clin Pharmacol       Date:  1987-08       Impact factor: 4.335

5.  Cefazolin and cephradine: relationship between serum concentrations and tissue contents in mice.

Authors:  M W Kunst; H Mattie
Journal:  Infection       Date:  1978       Impact factor: 3.553
  5 in total
  2 in total

1.  The importance of pharmacokinetics and pharmacodynamics for effective treatment of infections.

Authors:  H Mattie
Journal:  Clin Investig       Date:  1993-06

2.  The passage of cloxacillin into cerebrospinal fluid in the absence of meningitis.

Authors:  H I Schievink; H Mattie; R T Thomeer; E Van Strijen
Journal:  Br J Clin Pharmacol       Date:  1993-07       Impact factor: 4.335
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.