Literature DB >> 13898646

Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil).

J R GILLETTE, J V DINGELL, F SULSER, R KUNTZMAN, B B BRODIE.   

Abstract

Entities:  

Keywords:  BRAIN/metabolism; IMIPRAMINE/pharmacology

Mesh：

Substances：

Year:  1961        PMID： 13898646     DOI： 10.1007/bf02157980

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


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  4 in total

1.  On the mechanism of antidepressant action of imipraminelike drugs.

Authors:  F SULSER; J WATTS; B B BRODIE
Journal:  Ann N Y Acad Sci       Date:  1962-01-13       Impact factor: 5.691

2.  [Metabolism of the psychopharmacological agent tofranil].

Authors:  B HERRMANN; R PULVER
Journal:  Arch Int Pharmacodyn Ther       Date:  1960-07-01

3.  [Paper chromatographic determination of metabolic products of tofranil].

Authors:  B HERRMANN; W SCHINDLER; R PULVER
Journal:  Med Esp       Date:  1959

4.  [Treatment of depressive states with an iminodibenzyl derivative (G 22355)].

Authors:  R KUHN
Journal:  Schweiz Med Wochenschr       Date:  1957-08-31
  4 in total
  10 in total

Review 1.  The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression.

Authors:  Eleni Pitsillou; Sarah M Bresnehan; Evan A Kagarakis; Stevano J Wijoyo; Julia Liang; Andrew Hung; Tom C Karagiannis
Journal:  Mol Biol Rep       Date:  2019-10-14       Impact factor: 2.316

2.  Potentiation of tetrabenazine-induced behavioural depression by imipramine on a discrete-trial avoidance escape schedule.

Authors:  J I Székely; J Borsy; K Ildikó
Journal:  Psychopharmacologia       Date:  1974

3.  Tricyclic antidepressants.

Authors: 
Journal:  Br Med J       Date:  1968-04-13

4.  Clinical significance of plasma imipramine levels.

Authors:  C J Walter
Journal:  Proc R Soc Med       Date:  1971-03

5.  The analysis and disposition of imipramine and its active metabolites in man.

Authors:  T A Sutfin; C L DeVane; W J Jusko
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

6.  Dffects of imipramine on auditory sensitivity in the rat in relation to initial sensitivity.

Authors:  T Kameyama; T Shigehisa; T Nabeshima
Journal:  Psychopharmacology (Berl)       Date:  1976-07-28       Impact factor: 4.530

7.  Phase I metabolism of imipramine by microsomes of small intestine in comparison with metabolism by liver microsomes.

Authors:  W Christ; W Hecker; H Junge; G Stille
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-06       Impact factor: 3.000

8.  Preliminary pharmacological and clinical results with desmethylimipramine (DMI) G 35020, a metabolite of imipramine.

Authors:  B BRODIE; P DICK; P KIELHOLZ; W POELDINGER; W THEOBALD
Journal:  Psychopharmacologia       Date:  1961-12-19

9.  [ON THE METHODOLOGY OF RESEARCH ON ANTIDEPRESSIVE DRUGS WITH SPECIAL REFERENCE TO IMIPRAMINE (TOFRANIL) AND DESMETHYLIMIPRAMINE (PERTOFRAN)].

Authors:  H J HAASE; H KOESTER; M KOENIG; A BLEKER
Journal:  Arch Psychiatr Nervenkr       Date:  1963-09-18

10.  THE INCREASE IN THE TOXICITY OF YOHIMBINE INDUCED BY IMIPRAMINE AND OTHER DRUGS IN MICE.

Authors:  R M QUINTON
Journal:  Br J Pharmacol Chemother       Date:  1963-08
  10 in total

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