Literature DB >> 1388842

Virally induced immunosuppression.

R M Zinkernagel1, H Hengartner.   

Abstract

A mouse model of virus-triggered, T-cell mediated acquired immunosuppression is analyzed. Lymphocytic choriomeningitis virus initially infects mostly macrophages and antigen-presenting cells; these are destroyed by lymphocytic choriomeningitis virus specific cytotoxic T cells resulting in immunosuppression. Similar immunopathological mechanisms may play a role in acquired immune deficiency syndrome.

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Year:  1992        PMID： 1388842     DOI： 10.1016/s0952-7915(06)80031-2

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  3 in total

1.  Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major.

Authors:  Erika J Crosby; Megan Clark; Fernanda O Novais; E John Wherry; Phillip Scott
Journal:  J Immunol       Date:  2015-08-19       Impact factor: 5.422

2.  Pathogenesis of type II avian adenovirus infection in turkeys: in vivo immune cell tropism and tissue distribution of the virus.

Authors:  M Suresh; J M Sharma
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103

3.  Infection frequency of dendritic cells and CD4+ T lymphocytes in spleens of human immunodeficiency virus-positive patients.

Authors:  D McIlroy; B Autran; R Cheynier; S Wain-Hobson; J P Clauvel; E Oksenhendler; P Debré; A Hosmalin
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103
  3 in total

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