Literature DB >> 1388723

Evolutionary origins of the transforming growth factor-beta gene family.

D W Burt1, I R Paton.   

Abstract

A molecular phylogeny for the transforming growth factor-beta (TGF-beta) gene family based on a comparison of nucleotide sequences is proposed. A phylogenetic tree constructed from these sequences shows that the family evolved from a common ancestral gene that came into existence at about the time of arthropod and chordate divergence. This model suggests that the present day TGF-beta gene family consists of four members: TGF-beta 1 (= TGF-beta 4), TGF-beta 2, TGF-beta 3, and TGF-beta 5. The molecular phylogeny and Southern hybridization data also suggest that the proteins for mammalian TGF-beta 1 and chicken TGF-beta 4 are the products of homologous rather than duplicated genes. If the gene duplication event that produced the ancestral gene for TGF-beta 1 occurred before the divergence of birds and mammals, then sufficient time would have elapsed to generate these quite distinct avian and mammalian TGF-beta 1 proteins. Therefore, the TGF-beta family contains four distinct proteins, TGF-beta 1, 2, 3, and 5.

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Year:  1992        PMID： 1388723     DOI： 10.1089/dna.1992.11.497

Source DB:  PubMed          Journal:  DNA Cell Biol        ISSN： 1044-5498            Impact factor:   3.311


  8 in total

1.  Developmental regulation of neuronal KCa channels by TGFbeta 1: transcriptional and posttranscriptional effects mediated by Erk MAP kinase.

Authors:  L Lhuillier; S E Dryer
Journal:  J Neurosci       Date:  2000-08-01       Impact factor: 6.167

2.  Expression of mRNAs of multiple growth factors and receptors by astrocytes and glioma cells: detection with reverse transcription-polymerase chain reaction.

Authors:  A Zaheer; W Zhong; E Y Uc; D R Moser; R Lim
Journal:  Cell Mol Neurobiol       Date:  1995-04       Impact factor: 5.046

3.  Expression of mRNAs of multiple growth factors and receptors by neuronal cell lines: detection with RT-PCR.

Authors:  A Zaheer; W Zhong; R Lim
Journal:  Neurochem Res       Date:  1995-12       Impact factor: 3.996

Review 4.  TGF-β Control of Adaptive Immune Tolerance: A Break From Treg Cells.

Authors:  Ming Liu; Shun Li; Ming O Li
Journal:  Bioessays       Date:  2018-08-29       Impact factor: 4.345

5.  TGF-beta cooperates with TGF-alpha to induce the self-renewal of normal erythrocytic progenitors: evidence for an autocrine mechanism.

Authors:  O Gandrillon; U Schmidt; H Beug; J Samarut
Journal:  EMBO J       Date:  1999-05-17       Impact factor: 11.598

6.  Identification of a novel transforming growth factor-beta (TGF-beta6) gene in fish: regulation in skeletal muscle by nutritional state.

Authors:  Bruria Funkenstein; Elena Olekh; Sonia B Jakowlew
Journal:  BMC Mol Biol       Date:  2010-05-12       Impact factor: 2.946

7.  Autologous leukocyte-reduced platelet-rich plasma therapy for Achilles tendinopathy induced by collagenase in a rabbit model.

Authors:  Juan C González; Catalina López; María E Álvarez; Jorge E Pérez; Jorge U Carmona
Journal:  Sci Rep       Date:  2016-01-19       Impact factor: 4.379

8.  Molecular Evolution of Transforming Growth Factor-β (TGF-β) Gene Family and the Functional Characterization of Lamprey TGF-β2.

Authors:  Siqi Liu; Junfu Guo; Xianda Cheng; Wenna Li; Shuangyu Lyu; Xuanyi Chen; Qingwei Li; Hao Wang
Journal:  Front Immunol       Date:  2022-03-04       Impact factor: 7.561
  8 in total

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