Literature DB >> 1388651

Immunosuppression by ultraviolet B radiation: initiation by urocanic acid.

F P Noonan1, E C De Fabo.   

Abstract

Irradiation with UV-B, a component of natural sunlight, initiates systemic immunosuppression of delayed-type hypersensitivity responses. This may be a fundamental regulatory mechanism, controlling the interaction between mammals and potentially deleterious environmental UV radiation. Here, Frances Noonan and Edward De Fabo assess the evidence that suppression is initiated by the photoisomerization of trans-urocanic acid (UCA) in the stratum corneum, discuss the significance of this mechanism for skin cancer outgrowth and propose applications for UCA in transplantation.

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Year:  1992        PMID： 1388651     DOI： 10.1016/0167-5699(92)90005-R

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  33 in total

1.  Studies of delayed systemic effects of ultraviolet B radiation (UVR) on the induction of contact hypersensitivity, 2. Evidence that interleukin-10 from UVR-treated epidermis is the critical mediator.

Authors:  I Kurimoto; T Kitazawa; J W Streilein
Journal:  Immunology       Date:  2000-01       Impact factor: 7.397

2.  Urocanic acid as an efficient hydroxyl radical scavenger: a quantum theoretical study.

Authors:  Saumya Tiwari; Phool Chand Mishra
Journal:  J Mol Model       Date:  2010-04-02       Impact factor: 1.810

3.  Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses.

Authors:  P H Hart; A Jaksic; G Swift; M Norval; A A el-Ghorr; J J Finlay-Jones
Journal:  Immunology       Date:  1997-08       Impact factor: 7.397

Review 4.  How UV Light Touches the Brain and Endocrine System Through Skin, and Why.

Authors:  Andrzej T Slominski; Michal A Zmijewski; Przemyslaw M Plonka; Jerzy P Szaflarski; Ralf Paus
Journal:  Endocrinology       Date:  2018-05-01       Impact factor: 4.736

5.  The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers.

Authors:  A A Vink; A M Moodycliffe; V Shreedhar; S E Ullrich; L Roza; D B Yarosh; M L Kripke
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

6.  Characterization of a monoclonal antibody to cis-urocanic acid: detection of cis-urocanic acid in the serum of irradiated mice by immunoassay.

Authors:  A M Moodycliffe; M Norval; I Kimber; T J Simpson
Journal:  Immunology       Date:  1993-08       Impact factor: 7.397

7.  Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice.

Authors:  Lisa Biggs; Chunping Yu; Boris Fedoric; Angel F Lopez; Stephen J Galli; Michele A Grimbaldeston
Journal:  J Exp Med       Date:  2010-03-01       Impact factor: 14.307

8.  Control of UVB immunosuppression in the mouse by autosomal and sex-linked genes.

Authors:  F P Noonan; H A Hoffman
Journal:  Immunogenetics       Date:  1994       Impact factor: 2.846

9.  Exposure to UV Wavelengths in Sunlight Suppresses Immunity. To What Extent is UV-induced Vitamin D3 the Mediator Responsible?

Authors:  Prue H Hart; Shelley Gorman
Journal:  Clin Biochem Rev       Date:  2013-02

10.  Susceptibility to immunosuppression by ultraviolet B radiation in the mouse.

Authors:  F P Noonan; H A Hoffman
Journal:  Immunogenetics       Date:  1994       Impact factor: 2.846
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