| Literature DB >> 1388649 |
Abstract
The expression of MHC class I molecules protects cells against lysis by natural killer (NK) cells. It is possible that NK cells are 'educated' to recognize self MHC class I molecules and that the combination of self peptide and MHC class I molecule blocks NK-mediated lysis. Here, Rogier Versteeg compares and contrasts models of education and self-nonself discrimination by T cells and NK cells, and presents a hypothesis for the evolution of T cells from NK cells.Entities:
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Year: 1992 PMID： 1388649 DOI： 10.1016/0167-5699(92)90003-P
Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699