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Literature DB >> 13885652

Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro.

Abstract

Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37 degrees C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis.

Entities: Chemical Disease Species

Keywords: BLOOD PLATELETS; ESCHERICHIA COLI; TOXINS AND ANTITOXINS

Mesh：

Substances：

Year: 1961 PMID： 13885652 PMCID： PMC2180403 DOI： 10.1084/jem.114.6.857

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

24 in total

1. The release of histamine from rabbit platelets by means of antigen-antibody precipitates. I. The participation of the immune complex in histamine release.

Authors: J F BARBARO
Journal: J Immunol Date: 1961-04 Impact factor: 5.422

2. Mechanisms of the hemodynamic effects of endotoxin.

Authors: R P GILBERT
Journal: Physiol Rev Date: 1960-04 Impact factor: 37.312

3. Generation of coagulation product I and its interaction with platelets and phospholipids.

Authors: H I HOROWITZ; T H SPAET
Journal: J Appl Physiol Date: 1961-01 Impact factor: 3.531

4. Influence of perfusate characteristics on pulmonary vascular response to endotoxin.

Authors: L B HINSHAW; H KUIDA; R P GILBERT; M B VISSCHER
Journal: Am J Physiol Date: 1957-11

5. Serotonin and histamine release during anaphylaxis in the rabbit.

Authors: T P WAALKES; H WEISSBACH; J BOZICEVICH; S UDENFRIEND
Journal: J Clin Invest Date: 1957-07 Impact factor: 14.808

6. Pain-producing substance in human inflammatory exudates and plasma.

Authors: D ARMSTRONG; J B JEPSON; C A KEELE; J W STEWART
Journal: J Physiol Date: 1957-02-15 Impact factor: 5.182

7. Pharmacology of indole-alkylamines.

Authors: V ERSPAMER
Journal: Pharmacol Rev Date: 1954-12 Impact factor: 25.468

8. Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis.

Authors: C A STETSON
Journal: J Exp Med Date: 1951-05 Impact factor: 14.307

9. Comparative bactericidal activities of blood serum and plasma serum.

Authors: J G HIRSCH
Journal: J Exp Med Date: 1960-07-01 Impact factor: 14.307

10. Cellular source and charcter of a heatstable bactericidal property associated with rabbit and rat platelets.

Authors: R JAGO; R F JACOX
Journal: J Exp Med Date: 1961-04-01 Impact factor: 14.307

40 in total

1. Effect of pneumococci on blood clotting, platelets, and polymorphonuclear leukocytes.

Authors: J C Guckian
Journal: Infect Immun Date: 1975-10 Impact factor: 3.441

2. THE ROLE OF ENDOTOXIN DURING TYPHOID FEVER AND TULAREMIA IN MAN. II. ALTERED CARDIOVASCULAR RESPONSES TO CATECHOLAMINES.

Authors: S E GREISMAN; R B HORNIK; F A CAROZZA; T E WOODWARD
Journal: J Clin Invest Date: 1964-05 Impact factor: 14.808

9. Mechanisms of lipopolysaccharide-initiated rabbit platelet responses: alternative complement pathway dependence of the lytic response.

Authors: D C Morrison; L F Kline; Z G Oades; P M Henson
Journal: Infect Immun Date: 1978-06 Impact factor: 3.441

10. Interactions of the classical and alternate complement pathway with endotoxin lipopolysaccharide. Effect on platelets and blood coagulation.

Authors: M A Kane; J E May; M M Frank
Journal: J Clin Invest Date: 1973-02 Impact factor: 14.808