Literature DB >> 1388206

Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: a correction.

S Goldmann1, J Stoltefuss, L Born.   

Abstract

The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2-phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.

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Year:  1992        PMID： 1388206     DOI： 10.1021/jm00096a005

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  9 in total

1.  Cyclodextrine screening for the chiral separation of amlodipine enantiomers by capillary electrophoresis.

Authors:  Gabriel Hancu; Monica Budău; Lajos Kristóf Kántor; Anca Cârje
Journal:  Adv Pharm Bull       Date:  2015-03-05

2.  Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive.

Authors:  Min Lin; Oluyemi Aladejebi; Gregory H Hockerman
Journal:  Eur J Pharmacol       Date:  2011-09-02       Impact factor: 4.432

Review 3.  Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors.

Authors:  Rebecca Chaplin; Lyna Thach; Morley D Hollenberg; Yingnan Cao; Peter J Little; Danielle Kamato
Journal:  J Cell Commun Signal       Date:  2017-02-06       Impact factor: 5.782

4.  1,4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain.

Authors:  Chris Bladen; Vinicius M Gadotti; Miyase G Gündüz; N Daniel Berger; Rahime Şimşek; Cihat Şafak; Gerald W Zamponi
Journal:  Pflugers Arch       Date:  2014-07-03       Impact factor: 3.657

Review 5.  Actions of calcium channel blockers on vascular proteoglycan synthesis: relationship to atherosclerosis.

Authors:  Soniya Survase; Melanie E Ivey; Julie Nigro; Narin Osman; Peter J Little
Journal:  Vasc Health Risk Manag       Date:  2005

Review 6.  Formulations of Amlodipine: A Review.

Authors:  Muhammad Ali Sheraz; Syed Furqan Ahsan; Marium Fatima Khan; Sofia Ahmed; Iqbal Ahmad
Journal:  J Pharm (Cairo)       Date:  2016-10-16

7.  Comparative pharmacokinetics of a fixed-dose combination vs concomitant administration of telmisartan and S-amlodipine in healthy adult volunteers.

Authors:  Minkyung Oh; Sung-Eun Park; Jong-Lyul Ghim; Young-Kyung Choi; Eon-Jeong Shim; Jae-Gook Shin; Eun-Young Kim
Journal:  Drug Des Devel Ther       Date:  2017-12-11       Impact factor: 4.162

8.  Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects.

Authors:  Woo Youl Kang; Sook Jin Seong; Boram Ohk; Mi-Ri Gwon; Bo Kyung Kim; Sookie La; Hyun-Ju Kim; Seungil Cho; Young-Ran Yoon; Dong Heon Yang; Hae Won Lee
Journal:  Drug Des Devel Ther       Date:  2018-03-14       Impact factor: 4.162

9.  Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia.

Authors:  Kai-Xin Yao; Hang Lyu; Mei-Hua Liao; Lin Yang; Yin-Ping Gao; Qi-Bing Liu; Cheng-Kun Wang; Ying-Mei Lu; Guo-Jun Jiang; Feng Han; Ping Wang
Journal:  Sci Rep       Date:  2019-12-03       Impact factor: 4.379
  9 in total

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