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Literature DB >> 1388199

Huntington's disease in Chinese: a hypothesis of its origin.

C M Leung¹, Y W Chan, C M Chang, Y L Yu, C N Chen.

Abstract

The period prevalence (1984-91) of Huntington's disease (HD) in Hong Kong Chinese was 3.7 per million population. HD patients in Mainland China and Hong Kong showed similar hereditary pattern, clinical and pathological features as in the West. Chinese HD patients were male predominant with a younger age of onset and death. Their ancestral origin could be traced mostly to the coastal provinces of China. It is proposed that Chinese HD patients may have a European origin and share the same gene pool as their white counterparts.

Entities: Disease Species

Mesh：

Year: 1992 PMID： 1388199 PMCID： PMC489204 DOI： 10.1136/jnnp.55.8.681

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

12 in total

Huntington's disease in Chinese: a hypothesis of its origin.

1. Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families.

Review 2. Huntington's chorea: a centenary review.

3. Huntington's chorea (a clinical study).

4. Huntington's chorea in a Chinese family.

5. The mutation rate to Huntington's chorea.

6. Huntington's Chorea in South Wales. A genetic and epidemiological study.

7. Prevalence of Huntington's disease among UK immigrants from the Indian subcontinent.

Review 8. Huntington's disease: new approaches to an old problem. The Robert Wartenberg lecture.

9. Maternal factors in onset of Huntington disease.

10. Predictability of phenotype in Huntington's disease.

1. HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.

2. CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup.

3. Huntington's like conditions in China, A review of published Chinese cases.

4. The Prevalence of Juvenile Huntington's Disease: A Review of the Literature and Meta-Analysis.

Review 5. Incidence of adult Huntington's disease in the UK: a UK-based primary care study and a systematic review.

6. Survival of Korean Huntington's Disease Patients.