| Literature DB >> 1387343 |
M S Rao1, V Subbarao, A V Yeldandi, J K Reddy.
Abstract
The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats. We have examined the effect of dehydroepiandrosterone (DHEA), a steroid hormone with antimitotic and anticarcinogenic properties, on spontaneous Leydig cell tumorigenesis. Fifteen-week-old male F-344 rats were fed a diet containing DHEA (0.45% w/w) for 84 weeks. At the termination of experiment none of the 13 rats had Leydig cell hyperplasia or Leydig cell tumors. All the eight control rats of comparable age had Leydig cell tumors. These findings suggest that DHEA is a potent inhibitor of spontaneous Leydig cell tumors of testis in aged rats.Entities:
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Year: 1992 PMID： 1387343 DOI： 10.1016/0304-3835(92)90155-o
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679