| Literature DB >> 1387029 |
Abstract
Dorsal horn nociceptive neurones exhibit wind up, a frequency dependent potentiation of their responses to repeated C-fibre stimulation. Intrathecal morphine (5 micrograms) significantly reduces the initial responses of the neurones but not wind up whereas the reverse is true for N-methyl-D-aspartate (NMDA) antagonists. The combination of intrathecal morphine (5 micrograms) and 7-chlorokynurenate (2.5 micrograms), an antagonist at the glycine site of the NMDA receptor, abolishes both the input and wind up of these neurones.Entities:
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Year: 1992 PMID： 1387029 DOI： 10.1016/0006-8993(92)90780-d
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252