Literature DB >> 1386820

Brain D1 dopamine receptor in alloxan-induced diabetes.

M Salković1, Z Lacković.   

Abstract

Specific binding of [3H]SCH 23390 to dopamine D1 receptors in the striatum and olfactory tubercle in 14-day alloxan-induced diabetic rats was investigated. The Scatchard analysis revealed decreased D1 receptor density in the striatum (Bmax values were 548 +/- 23 fmol/mg protein for the control and 466 +/- 33 fmol/mg for the diabetic rats). No change was observed in the olfactory tubercle (Bmax; 299 +/- 27 fmol/mg for the control and 317 +/- 32 fmol/mg for the diabetic rats). Thus, specific binding of [3H]SCH 23390 to striatal and olfactory tubercle membranes showed region-specific changes of brain dopamine D1 receptors in alloxan diabetic rats.

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Year:  1992        PMID： 1386820     DOI： 10.2337/diab.41.9.1119

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  4 in total

1.  Striatal dopaminergic D1 and D2 receptors after intracerebroventricular application of alloxan and streptozocin in rat.

Authors:  M Salković; I Sabolić; Z Lacković
Journal:  J Neural Transm Gen Sect       Date:  1995

2.  The Effect of Systemic Delivery of Aminoguanidine versus Doxycycline on the Resorptive Phase of Alveolar Bone Following modified Widman Flap in Diabetic Rats: A Histopathological and Scanning Electron Microscope (SEM) study.

Authors:  E Tella; S Aldahlawi; A Eldeeb; H El Gazaerly
Journal:  Int J Health Sci (Qassim)       Date:  2014-07

3.  Changes in the central dopaminergic systems in the streptozotocin-induced diabetic rats.

Authors:  D K Lim; K M Lee; I K Ho
Journal:  Arch Pharm Res       Date:  1994-12       Impact factor: 4.946

Review 4.  Cerebral function in diabetes mellitus.

Authors:  G J Biessels; A C Kappelle; B Bravenboer; D W Erkelens; W H Gispen
Journal:  Diabetologia       Date:  1994-07       Impact factor: 10.122
  4 in total

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