Literature DB >> 13867755

On the mechanism of action of Colisan.

F BERGMANN, M CHAIMOVITZ, S LEON, B PREISS.   

Abstract

Purified Colisan produces instantaneous lysis of paramecia and amoebae, and blebbing of paramecia, rat mast cells and ascites tumour cells. Colisan liberates histamine from mast cells. It also suppresses competitively the bradykinin-provoked contraction of the guinea-pig ileum. Most of these effects are not shared by staphylococcus-haemolysin. The results suggest a rapid change of the permeability of the cell membrane as the mechanism of all the diversified biological actions of Colisan.

Entities:  

Keywords:  AMEBICIDES/pharmacology; ANTIBIOTICS/pharmacology; MAST CELLS/pharmacology; NEOPLASMS/therapy; PARAMECIUM/pharmacology

Mesh：

Substances：

Year:  1962        PMID： 13867755      PMCID： PMC1482114          DOI： 10.1111/j.1476-5381.1962.tb01410.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  7 in total

1.  A comparative study of staphylococcus haemolysins and Colisan.

Authors:  F BERGMANN; S LEON; M CHAIMOVITZ; F BENZAKEIN
Journal:  Br J Pharmacol Chemother       Date:  1961-10

2.  Studies with the immobilization reaction in the genus Entamoeba.

Authors:  V ZAMAN
Journal:  Ann Trop Med Parasitol       Date:  1960-12

3.  Some pharmacological properties of the alpha-toxin of staphylococcus pyogenes.

Authors:  D A BROWN; B N PRICHARD; J P QUILLIAM
Journal:  Br J Pharmacol Chemother       Date:  1959-03

4.  Pharmacological study of a new antibiotic of bacillary origin.

Authors:  F BERGMANN; R REITLER; M CHAIMOVITZ; D BERGMANN
Journal:  Br J Pharmacol Chemother       Date:  1960-06

5.  Studies with staphylococcal toxins. V. Possible identification of alpha hemolysin with a proteolytic enzyme.

Authors:  J ROBINSON; F S THATCHER; J MONTFORD
Journal:  Can J Microbiol       Date:  1960-04       Impact factor: 2.419

6.  Cytologic studies with the phase Microscope; the formation of blisters on cells in suspension, photocytosis, with observations on the nature of the cellular membrane.

Authors:  H U ZOLLINGER
Journal:  Am J Pathol       Date:  1948-05       Impact factor: 4.307

7.  The antigenic composition of mouse ascites tumour cells using in vitro and gel-diffusion techniques.

Authors:  G C EASTY; E J AMBROSE
Journal:  Br J Cancer       Date:  1957-06       Impact factor: 7.640
  7 in total
  1 in total

1.  Dual action of nitroparaffins on the guinea-pig ileum.

Authors:  F BERGMANN; M CHAIMOVITZ; E WIND
Journal:  Br J Pharmacol Chemother       Date:  1962-04
  1 in total

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