Interrelationships among ECHO virus types 1,8, and 12.

Berg, Gerald (Robert A. Taft Sanitary Engineering Center, Cincinnati, Ohio), Norman A. Clarke, and Paul W. Kabler. Interrelationships among ECHO virus types 1, 8, and 12. J. Bacteriol. 83:556-560. 1962.-Antigenic relationships among ECHO 1, 8, and 12 viruses were investigated. Three strains of ECHO 1 virus, one of which had been purified, could not be differentiated by neutralization tests. Antiserums produced with these three strains neutralized ECHO 12 virus. The neutralizing material, absent from preimmunization serums, was not absorbed by rhesus kidney cells, was heat-stable, and, therefore, may be viral antibody. Reciprocal neutralization was achieved with all three types. Disagreement of these data with those published by others is discussed.