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Literature DB >> 13867378

Studies on sympathetic mechanisms in isolated intestinal and vas deferens preparations.

Abstract

The effects of various drugs which block sympathetic nerves have been studied in Finkleman preparations of rabbit and cat ileum. Contractile responses could be produced in many cases after the normal inhibitory responses to periarterial nerve stimulation had been blocked. In almost all cases this contractile response was abolished by ganglion-blocking drugs. The normal rabbit ileum Finkleman preparation was found to behave differently towards bretylium than do preparations taken from animals treated with reserpine. The block of the guinea-pig isolated hypogastric vas deferens preparation caused by hemicholinium HC-3 was found to be reversed in the presence of noradrenaline, histamine, or 5-hydroxytryptamine, as was the block caused by guanethidine and bretylium. The results are discussed in relation to the Burn-Rand theory of sympathetic nerve mechanism.

Entities: Chemical Species

Keywords: ILEUM/physiology; SYMPATHETIC NERVOUS SYSTEM/physiology; VAS DEFERENS/physiology

Mesh：

Substances：

Year: 1962 PMID： 13867378 PMCID： PMC1482230 DOI： 10.1111/j.1476-5381.1962.tb01429.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

18 in total

1. The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catechol amines and by DOPA.

Authors: J S GILLESPIE; B R MACKENNA
Journal: J Physiol Date: 1961-04 Impact factor: 5.182

1. AN ANALYSIS OF THE BLOCKING ACTION OF DIMETHYLPHENYLPIPERAZINIUM IODINE ON THE INHIBITION OF ISOLATED SMALL INTESTINE PRODUCED BY STIMULATION OF SYMPATHETIC NERVES.

Authors: A T BIRMINGHAM; A B WILSON
Journal: Br J Pharmacol Chemother Date: 1965-04

2. INDEPENDENT CHOLINERGIC AND ADRENERGIC MECHANISMS IN THE GUINEA-PIG ISOLATED NERVE-VAS DEFERENS PREPARATION.

Authors: K P BHARGAVA; K KAR; S S PARMAR
Journal: Br J Pharmacol Chemother Date: 1965-06

3. Potentiation of responses to noradrenaline and reversal of sympathetic nerve blockade in the guinea-pig vas deferens.

Authors: G A Bentley
Journal: Br J Pharmacol Chemother Date: 1965-08

4. Effects of cocaine and of monoamine oxidase and catechol-o-methyl transferase inhibitors on transmission to the guinea-pig vas deferens.

Authors: C Bell
Journal: Br J Pharmacol Chemother Date: 1967-10

5. An analysis of the responses of the isolated portal vein of the rabbit to electrical stimulation and to drugs.

Authors: J Hughes; J R Vane
Journal: Br J Pharmacol Chemother Date: 1967-05

6. An analysis of the sympathomimetic effects of acetylcholine of the rat ileum.

Authors: S D Gokhale; O D Gulati; D I Panchal
Journal: Br J Pharmacol Chemother Date: 1967-05

7. Postganglionic paralysis of the guinea-pig hypogastric nerve-vas deferens preparation by Clostridium botulinum type D toxin.

Authors: D A Westwood; B C Whaler
Journal: Br J Pharmacol Chemother Date: 1968-05

8. The effects of cholinomimetic drugs on responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery.

Authors: M J Rand; B Varma
Journal: Br J Pharmacol Date: 1970-04 Impact factor: 8.739

9. New type of nerve-mediated cholinergic contractions of the guinea-pig small intestine and its selective blockade by capsaicin.

Authors: J Szolcsányi; L Barthó
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1978-10 Impact factor: 3.000

10. The action of substances which block sympathetic postganglionic nervous transmission.

Authors: J H BURN; H FROEDE
Journal: Br J Pharmacol Chemother Date: 1963-04

Studies on sympathetic mechanisms in isolated intestinal and vas deferens preparations.

1. The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catechol amines and by DOPA.

2. Lack of evidence for a cholinergic mechanism in sympathetic transmission.

3. The peripheral cardiovascular actions of guanethidine in dogs.

4. Postsynaptic action of HC-3 on neuromuscular transmission.

5. Sympathetic postganglionic cholinergic fibres.

6. On the nature of inhibition in the intestine.

7. Fluid electrodes with a rubber diaphragm.

8. Transmission failure in sympathetic nerves produced by hemicholinium.

9. The actions of bretylium: adrenergic neurone blocking and other effects.

10. Effect of guanethidine in revealing cholinergic sympathetic fibres.