| Literature DB >> 1386318 |
C Fargeas1, C Y Wu, T Nakajima, D Cox, T Nutman, G Delespesse.
Abstract
(TGF)-beta is a pluripotent cytokine exerting differential effects on distinct components of the immune response. The present report, based on lymphokine determination in culture supernatants and Northern blot analysis of lymphokine mRNA, demonstrates that TGF-beta 2 markedly inhibits interleukin (IL)-4 and IL-5 synthesis by polyclonally activated human T cells in the absence of any significant effect on (IFN)-gamma, lymphotoxin or IL-2, suggesting a modulatory effect of TGF-beta 2 on the interferon Th1/Th2) balance of immune responses. The inhibitory effect of TGF-beta on IFN-gamma production by unfractionated peripheral blood mononuclear cells is likely to reflect the blunting of natural killer cell activation by TGF-beta.Entities:
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Year: 1992 PMID： 1386318 DOI： 10.1002/eji.1830220833
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532