| Literature DB >> 1386162 |
T Inaba1, W M Roberts, L H Shapiro, K W Jolly, S C Raimondi, S D Smith, A T Look.
Abstract
A t(17;19) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed in liver and kidney, but not in lymphoid cells, and was found to be closely related to the leucine zipper-containing transcription factors DBP (albumin D-box binding protein) and TEF (thyrotroph embryonic factor), which regulate developmental stage-specific gene expression.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1386162 DOI： 10.1126/science.1386162
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728