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Literature DB >> 1385941

Pityriasis rosea and discoid eczema: dose related reactions to treatment with gold.

S M Wilkinson¹, A G Smith, M J Davis, D Mattey, P T Dawes.

Abstract

Sixteen cases of either a pityriasiform or discoid eczematous rash occurring in patients with rheumatoid arthritis receiving treatment with gold (sodium aurothiomalate and auranofin) were studied. The results suggest that this is a dose related, not allergic, reaction to gold. The development of this rash is not an absolute indication to stop treatment with gold. Control can often be effected with potent topical steroids or a reduction in the dose or frequency of treatment with gold.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1992 PMID： 1385941 PMCID： PMC1004773 DOI： 10.1136/ard.51.7.881

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

12 in total

1. Gold dermatitis. A clinical and histopathological study.

Authors: N S Penneys; A B Ackerman; N L Gottlieb
Journal: Arch Dermatol Date: 1974-03

2. Gold concentrations in hair, nail, and skin during chrysotherapy.

Authors: N L Gottlieb; P M Smith; N S Penneys; E M Smith
Journal: Arthritis Rheum Date: 1974 Jan-Feb

3. Immunological studies on the mechanism of gold hypersensitivity reactions.

Authors: P Davis; A Ezeoke; J Munro; J R Hobbs; G R Hughes
Journal: Br Med J Date: 1973-09-29

4. The lymphocyte transformation test and gold hypersensitivity.

Authors: E J Denman; A M Denman
Journal: Ann Rheum Dis Date: 1968-11 Impact factor: 19.103

5. The significance of an IgM band at the dermo-epidermal junction.

Authors: F Wojnarowska; B Bhogal; M M Black
Journal: J Cutan Pathol Date: 1986-10 Impact factor: 1.587

6. Inhibition of prostaglandin synthesis and human epidermal enzymes by aurothiomalate in vitro: possible actions of gold in pemphigus.

Authors: N S Penneys; V Ziboh; N L Gottlieb; S Katz
Journal: J Invest Dermatol Date: 1974-10 Impact factor: 8.551

Pityriasis rosea and discoid eczema: dose related reactions to treatment with gold.

1. Gold dermatitis. A clinical and histopathological study.

2. Gold concentrations in hair, nail, and skin during chrysotherapy.

3. Immunological studies on the mechanism of gold hypersensitivity reactions.

4. The lymphocyte transformation test and gold hypersensitivity.

5. The significance of an IgM band at the dermo-epidermal junction.

6. Inhibition of prostaglandin synthesis and human epidermal enzymes by aurothiomalate in vitro: possible actions of gold in pemphigus.

Review 7. Complications of chrysotherapy: a review of recent studies.

8. Direct immunofluorescence of normal skin in rheumatoid arthritis.

9. Pityriasis rosea-like rash from captopril.

10. Association between gold induced skin rash and remission in patients with rheumatoid arthritis.

1. Cutaneous adverse events in multiple sclerosis patients treated with daclizumab.

Review 2. Clinical variants of pityriasis rosea.