Literature DB >> 1385297

Genetic and physical map of the interferon region on chromosome 9p.

J W Fountain1, M Karayiorgou, D Taruscio, S L Graw, A J Buckler, D C Ward, N C Dracopoli, D E Housman.   

Abstract

A region of chromosome 9, surrounding the interferon-beta (IFNB1) locus and the interferon-alpha (IFNA) gene cluster on 9p13-p22, has been shown to be frequently deleted or rearranged in a number of human cancers, including leukemia, glioma, non-small-cell lung carcinoma, and melanoma. To assist in better defining the precise region(s) of 9p implicated in each of these malignancies, a combined genetic and physical map of this region was generated using the available 9p markers IFNB1, IFNA, D9S3, and D9S19, along with a newly described locus, D9S126. The relative order and distances between these loci were determined by multipoint linkage analysis of CEPH (Centre d'Etude du Polymorphisme Humain) pedigree DNAs, pulsed-field gel electrophoresis, and fluorescence in situ hybridization. All three mapping approaches gave concordant results and, in the case of multipoint linkage analysis, the following gene order was supported for these and other closely linked chromosome 9 markers present in the CEPH database: pter-D9S33-IFNB1/IFNA-D9S126-D9S3-D9S19 -D9S9/D9S15-ASSP3-qter. This map serves to extend preexisting chromosome 9 maps (which focus primarily on 9q) and also reassigns D9S3 and D9S19 to more proximal locations on 9p.

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Year:  1992        PMID： 1385297     DOI： 10.1016/s0888-7543(05)80290-3

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  14 in total

1.  An index marker map of chromosome 9 provides strong evidence for positive interference.

Authors:  D J Kwiatkowski; C Dib; S A Slaugenhaupt; S Povey; J F Gusella; J L Haines
Journal:  Am J Hum Genet       Date:  1993-12       Impact factor: 11.025

2.  Polymorphisms in the Tcrb-V2 gene segments localize the Tcrb orphon genes to human chromosome 9p21.

Authors:  P Charmley; S Wei; P Concannon
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846

3.  Diaphyseal medullary stenosis with malignant fibrous histiocytoma: a hereditary bone dysplasia/cancer syndrome maps to 9p21-22.

Authors:  J A Martignetti; R J Desnick; E Aliprandis; K I Norton; P Hardcastle; S Nade; B D Gelb
Journal:  Am J Hum Genet       Date:  1999-03       Impact factor: 11.025

4.  Confirmation of chromosome 9p linkage in familial melanoma.

Authors:  D J Nancarrow; G J Mann; E A Holland; G J Walker; S C Beaton; M K Walters; C Luxford; J M Palmer; J A Donald; J L Weber
Journal:  Am J Hum Genet       Date:  1993-10       Impact factor: 11.025

5.  Regional localization of the rat genes encoding the cAMP-specific phosphodiesterases 3 (Pde4d) and 4 (Pde4b) and the tyrosinase-related protein 1 (Tyrp1).

Authors:  F Tissir; B Champagne; K Klinga-Levan; G Levan; J Szpirer; C Szpirer
Journal:  Mamm Genome       Date:  1996-03       Impact factor: 2.957

6.  Genetic instability in human ovarian cancer cell lines.

Authors:  K Orth; J Hung; A Gazdar; A Bowcock; J M Mathis; J Sambrook
Journal:  Proc Natl Acad Sci U S A       Date:  1994-09-27       Impact factor: 11.205

7.  Molecular definition of a chromosome 9p21 germ-line deletion in a woman with multiple melanomas and a plexiform neurofibroma: implications for 9p tumor-suppressor gene(s).

Authors:  E M Petty; L H Gibson; J W Fountain; J L Bolognia; T L Yang-Feng; D E Housman; A E Bale
Journal:  Am J Hum Genet       Date:  1993-07       Impact factor: 11.025

8.  Homozygous deletions on the short arm of chromosome 9 in ovarian adenocarcinoma cell lines and loss of heterozygosity in sporadic tumors.

Authors:  G Chenevix-Trench; J Kerr; M Friedlander; T Hurst; B Sanderson; M Coglan; B Ward; J Leary; S K Khoo
Journal:  Am J Hum Genet       Date:  1994-07       Impact factor: 11.025

9.  Homozygous deletions within human chromosome band 9p21 in melanoma.

Authors:  J W Fountain; M Karayiorgou; M S Ernstoff; J M Kirkwood; D R Vlock; L Titus-Ernstoff; B Bouchard; S Vijayasaradhi; A N Houghton; J Lahti
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

10.  Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

Authors:  O I Olopade; H M Pomykala; F Hagos; L W Sveen; R Espinosa; M H Dreyling; S Gursky; W M Stadler; M M Le Beau; S K Bohlander
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205
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