Literature DB >> 1385177

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels.

A W Schmidt1, S McLean, J Heym.   

Abstract

The nonpeptide substance P receptor antagonist CP-96,345 was found to displace binding to Ca2+ channel binding sites labelled with either [3H]desmethoxyverapamil or [3H]diltiazem and to enhance [3H]nitrendipine binding. Unlike the substance P receptor antagonist activity of CP-96,345, these effects on Ca2+ channel binding sites were neither stereoselective nor species-dependent. It is concluded that CP-96,345 may act as an antagonist of L-type Ca2+ channels in addition to being a potent NK1 receptor (substance P) antagonist.

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Year:  1992        PMID： 1385177     DOI： 10.1016/0014-2999(92)90498-s

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  17 in total

1.  Inhibitory action of (+/-)CP-96,345 on the cardiovascular responses to intrathecal substance P and neuropeptide K in the conscious freely moving rat.

Authors:  T M Pham; R Couture
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

2.  Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.

Authors:  A Zimmer; A M Zimmer; J Baffi; T Usdin; K Reynolds; M König; M Palkovits; E Mezey
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

3.  Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice.

Authors:  Annika Thorsell; Jesse R Schank; Erick Singley; Stephen P Hunt; Markus Heilig
Journal:  Psychopharmacology (Berl)       Date:  2010-01-30       Impact factor: 4.530

4.  Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat.

Authors:  E Cellier; L Barbot; S Iyengar; R Couture
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

5.  Tachykinin NK1 and NK2 receptor antagonists and atropine-resistant ascending excitatory reflex to the circular muscle of the guinea-pig ileum.

Authors:  C A Maggi; R Patacchini; L Bartho; P Holzer; P Santicioli
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

6.  Block of voltage-dependent sodium currents by the substance P receptor antagonist (+/-)-CP-96,345 in neurones cultured from rat cortex.

Authors:  M Caeser; G R Seabrook; J A Kemp
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

7.  Selective inhibition of the carotid body sensory response to hypoxia by the substance P receptor antagonist CP-96,345.

Authors:  N R Prabhakar; H Cao; J A Lowe; R M Snider
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

8.  Antinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99,994, in conscious gerbils.

Authors:  N M Rupniak; J K Webb; A R Williams; E Carlson; S Boyce; R G Hill
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

9.  Acid-induced mesenteric hyperemia in rats: role of CGRP, substance P, prostaglandin, adenosine, and histamine.

Authors:  Felix W Leung; Fumihiro Iwata; Kyoji Seno; Joseph W C Leung
Journal:  Dig Dis Sci       Date:  2003-03       Impact factor: 3.199

10.  Neurogenic peptides and the cardiomyopathy of magnesium-deficiency: effects of substance P-receptor inhibition.

Authors:  W B Weglicki; I T Mak; R E Stafford; B F Dickens; M M Cassidy; T M Phillips
Journal:  Mol Cell Biochem       Date:  1994-01-26       Impact factor: 3.396
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