A review of recent studies of goitre in Italy.

The prevalence and distribution of both epidemic and endemic goitre in Italy since 1940 are reviewed and the main results of recent research into these two forms of the disease are specified.A number of epidemic outbreaks occurred between 1940 and 1948, all originally in areas of endemic goitre but sometimes spreading to localities from which endemic goitre had practically disappeared. Both persons long resident in these areas and new arrivals were affected, as were domestic animals. Acute goitres showed the same histological features as in the endemic form of the disease. Extrathyroid symptoms were sometimes noted.Studies of endemic goitre have failed to show any clear indication that lack of iodine is responsible for the condition. Epidemiologically, endemic goitre, which remains a predominantly rural disease, seems to be shifting gradually from northern to southern Italy.