Literature DB >> 1384808

Embryonic expression and functional analysis of a Xenopus activin receptor.

A Hemmati-Brivanlou1, D A Wright, D A Melton.   

Abstract

We report the isolation and characterization of a Xenopus activin receptor (XAR1). The amino acid sequence of this protein shows extensive homology with a murine activin receptor. The mRNA is expressed maternally and is ubiquitously distributed during the early stages of embryogenesis. Consistent with a possible role in mesoderm induction and patterning, interference with the normal expression of the receptor by overexpression in the early embryo results in the formation of ectopic dorsal axial structures. During neurulation the XAR1 mRNA is expressed predominantly in the presumptive brain and spinal cord, suggesting an additional function for XAR1 in neurogenesis.

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Year:  1992        PMID： 1384808     DOI： 10.1002/aja.1001940102

Source DB:  PubMed          Journal:  Dev Dyn        ISSN： 1058-8388            Impact factor:   3.780


  8 in total

1.  The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.

Authors:  E Reissmann; H Jörnvall; A Blokzijl; O Andersson; C Chang; G Minchiotti; M G Persico; C F Ibáñez; A H Brivanlou
Journal:  Genes Dev       Date:  2001-08-01       Impact factor: 11.361

2.  Different spatial distribution of mRNAs for activin receptors (type IIA and IIB) and follistatin in developing embryos of Xenopus laevis.

Authors:  C Koga; K Tashiro; K Shiokawa
Journal:  Rouxs Arch Dev Biol       Date:  1995-01

3.  A submicroscopic deletion in Xq26 associated with familial situs ambiguus.

Authors:  G B Ferrero; M Gebbia; G Pilia; D Witte; A Peier; R J Hopkin; W J Craigen; L G Shaffer; D Schlessinger; A Ballabio; B Casey
Journal:  Am J Hum Genet       Date:  1997-08       Impact factor: 11.025

4.  Further analysis of cytoplasmic polyadenylation in Xenopus embryos and identification of embryonic cytoplasmic polyadenylation element-binding proteins.

Authors:  R Simon; J D Richter
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

Review 5.  Neural induction and factors that stabilize a neural fate.

Authors:  Crystal D Rogers; Sally A Moody; Elena S Casey
Journal:  Birth Defects Res C Embryo Today       Date:  2009-09

6.  Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?

Authors:  S Schulte-Merker; J C Smith; L Dale
Journal:  EMBO J       Date:  1994-08-01       Impact factor: 11.598

7.  The response of early neural genes to FGF signaling or inhibition of BMP indicate the absence of a conserved neural induction module.

Authors:  Crystal D Rogers; George S Ferzli; Elena S Casey
Journal:  BMC Dev Biol       Date:  2011-12-15       Impact factor: 1.978

8.  Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors.

Authors:  Simon K Cheng; Felix Olale; Ali H Brivanlou; Alexander F Schier
Journal:  PLoS Biol       Date:  2004-02-17       Impact factor: 8.029
  8 in total

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