Literature DB >> 1384682

The der(11) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemia.

J D Rowley1.   

Abstract

Translocations involving 11q23 are recurring abnormalities in human acute leukemia cells of either lymphoid or myeloid lineage. Analysis of 13 variant translocations associated with four of these [t(4;11), t(6;11), t(9;11) and t(11;19)] reveals that the der(11) chromosome is conserved in all of them and therefore contains the critical genetic rearrangement. The MLL gene (myeloid/lymphoid leukemia) is involved in each of these translocations. It is transcribed from centromere to telomere. The present analysis indicates that the 5' region of MLL on the der(11) is juxtaposed to the coding sequences of genes on each of the other translocation partners.

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Year:  1992        PMID： 1384682     DOI： 10.1002/gcc.2870050316

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  7 in total

1.  Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.

Authors:  P H Domer; S S Fakharzadeh; C S Chen; J Jockel; L Johansen; G A Silverman; J H Kersey; S J Korsmeyer
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

2.  11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

Authors:  N J Zeleznik-Le; A M Harden; J D Rowley
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

3.  EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.

Authors:  C W So; C Caldas; M M Liu; S J Chen; Q H Huang; L J Gu; M H Sham; L M Wiedemann; L C Chan
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

4.  Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

Authors:  M J Thirman; D A Levitan; H Kobayashi; M C Simon; J D Rowley
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205

5.  Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.

Authors:  P H Sorensen; C S Chen; F O Smith; D C Arthur; P H Domer; I D Bernstein; S J Korsmeyer; G D Hammond; J H Kersey
Journal:  J Clin Invest       Date:  1994-01       Impact factor: 14.808

6.  Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

Authors:  J Corral; A Forster; S Thompson; F Lampert; Y Kaneko; R Slater; W G Kroes; C E van der Schoot; W D Ludwig; A Karpas
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

7.  A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.

Authors:  W T Wong; C Schumacher; A E Salcini; A Romano; P Castagnino; P G Pelicci; P P Di Fiore
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-10       Impact factor: 11.205
  7 in total

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