Literature DB >> 1384681

Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp.

J A Fletcher1, J L Pinkus, J M Lage, C C Morton, G S Pinkus.   

Abstract

Previous cytogenetic analyses revealed t(6;20)(p21;q13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q13). Subsequent combined immunohistochemical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.

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Year:  1992        PMID： 1384681     DOI： 10.1002/gcc.2870050315

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  8 in total

1.  Stromal p16 expression differentiates endometrial polyp from endometrial hyperplasia.

Authors:  Suzuko Moritani; Shu Ichihara; Masaki Hasegawa; Akari Iwakoshi; Sakae Murakami; Tomoko Sato; Tomomitsu Okamoto; Yoshio Mori; Hajime Kuhara; Steven G Silverberg
Journal:  Virchows Arch       Date:  2012-07-07       Impact factor: 4.064

2.  Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change.

Authors:  J W Carlson; G L Mutter
Journal:  Histopathology       Date:  2008-07-15       Impact factor: 5.087

3.  Diagnosis of premalignant endometrial disease.

Authors:  G L Mutter
Journal:  J Clin Pathol       Date:  2002-05       Impact factor: 3.411

4.  Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer.

Authors:  Pradeep S Tanwar; LiHua Zhang; Drucilla J Roberts; Jose M Teixeira
Journal:  Cancer Res       Date:  2011-03-01       Impact factor: 12.701

5.  HMGI(Y) expression in human uterine leiomyomata. Involvement of another high-mobility group architectural factor in a benign neoplasm.

Authors:  A J Williams; W L Powell; T Collins; C C Morton
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

6.  Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias.

Authors:  J E Tate; G L Mutter; K A Boynton; C P Crum
Journal:  Am J Pathol       Date:  1997-01       Impact factor: 4.307

7.  Chromosomal Translocation t(5;12)(p13;q14) Leading to Fusion of High-mobility Group AT-hook 2 Gene With Intergenic Sequences From Chromosome Sub-Band 5p13.2 in Benign Myoid Neoplasms of the Breast: A Second Case.

Authors:  Ioannis Panagopoulos; Ludmila Gorunova; Kristin Andersen; Marius Lund-Iversen; Hanne Regine Hognestad; Ingvild Lobmaier; Francesca Micci; Sverre Heim
Journal:  Cancer Genomics Proteomics       Date:  2022 Jul-Aug       Impact factor: 3.395

8.  Malignant endometrial polyps: Report of two cases and review of literature with emphasize on recent advances.

Authors:  Ali Dastranj Tabrizi; Amir Vahedi; Hiedar Ali Esmaily
Journal:  J Res Med Sci       Date:  2011-04       Impact factor: 1.852
  8 in total

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